Food group intake and the risk of oral epithelial dysplasia in a United States population

Douglas E. Morse, David G. Pendrys, Ralph Katz, Theodore R. Holford, David J. Krutchkoff, Ellen Eisenberg, Diane L. Kosis, Stanley Kerpel, Paul Freedman, Susan T. Mayne

Research output: Contribution to journalArticle

Abstract

Objectives: Oral epithelial dysplasia (OED) is a histopathologic diagnosis associated with an increased risk of oral cancer. The paper explores the relationship between OED risk and food group intake. Methods: In this case-control study, incident cases of OED were identified through two oral pathology laboratories. Controls, pair-matched 1:1 to cases on age (± 5 years), gender, appointment date (± 1 year), and surgeon, were identified through the office in which the respective case was biopsied. Exposure data were obtained via a telephone interview and mailed food-frequency questionnaire. Conditional logistic regression was used to obtain odds ratio point estimates. Results: Based upon 87 matched pairs - and after controlling for smoking, drinking, and other potential covariates-there was an apparent inverse relationship between OED risk and the consumption of fruits and vegetables, with the intake of these foods being associated with a strong attenuating effect among smokers. OED risk decreased with increased poultry consumption, but increased modestly with bread/cereal and dairy food intake. Conclusions: This investigation provides evidence that some aspects of diet may be associated with the risk of OED. It also suggests that in oral carcinogenesis the role of diet is not simply one of a late effect.

Original languageEnglish (US)
Pages (from-to)713-720
Number of pages8
JournalCancer Causes and Control
Volume11
Issue number8
DOIs
StatePublished - 2000

Fingerprint

Eating
Population
Oral Pathology
Diet
Mouth Neoplasms
Bread
Poultry
Vegetables
Drinking
Case-Control Studies
Fruit
Appointments and Schedules
Carcinogenesis
Logistic Models
Smoking
Odds Ratio
Interviews
Food

Keywords

  • Diet
  • Dysplasia
  • Mouth neoplasms
  • Precancerous conditions
  • Risk factors

ASJC Scopus subject areas

  • Cancer Research
  • Epidemiology
  • Oncology

Cite this

Morse, D. E., Pendrys, D. G., Katz, R., Holford, T. R., Krutchkoff, D. J., Eisenberg, E., ... Mayne, S. T. (2000). Food group intake and the risk of oral epithelial dysplasia in a United States population. Cancer Causes and Control, 11(8), 713-720. https://doi.org/10.1023/A:1008943904085

Food group intake and the risk of oral epithelial dysplasia in a United States population. / Morse, Douglas E.; Pendrys, David G.; Katz, Ralph; Holford, Theodore R.; Krutchkoff, David J.; Eisenberg, Ellen; Kosis, Diane L.; Kerpel, Stanley; Freedman, Paul; Mayne, Susan T.

In: Cancer Causes and Control, Vol. 11, No. 8, 2000, p. 713-720.

Research output: Contribution to journalArticle

Morse, DE, Pendrys, DG, Katz, R, Holford, TR, Krutchkoff, DJ, Eisenberg, E, Kosis, DL, Kerpel, S, Freedman, P & Mayne, ST 2000, 'Food group intake and the risk of oral epithelial dysplasia in a United States population', Cancer Causes and Control, vol. 11, no. 8, pp. 713-720. https://doi.org/10.1023/A:1008943904085
Morse, Douglas E. ; Pendrys, David G. ; Katz, Ralph ; Holford, Theodore R. ; Krutchkoff, David J. ; Eisenberg, Ellen ; Kosis, Diane L. ; Kerpel, Stanley ; Freedman, Paul ; Mayne, Susan T. / Food group intake and the risk of oral epithelial dysplasia in a United States population. In: Cancer Causes and Control. 2000 ; Vol. 11, No. 8. pp. 713-720.
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