Folate, vitamin B-12 and riboflavin status of active and sedentary elderly women with Rheumatoid Arthritis (RA)

Kathleen Woolf, M. M. Manore, K. S. Matt

Research output: Contribution to journalArticle

Abstract

Arthritis is the most frequent and disabling chronic illness for older adults, especially women. This study examined the relationship between physical activity (≥ 4 h/wk for ≥ 5 y), nutrition and RA in women (56-77 y; mean BMI = 24.5 kg/m2; mean body fat = 41%). Subjects were classified into 4 groups: active with RA (n=12); sedentary with RA (n=13); active without RA (n=11); sedentary without RA (n=13). Diet and supplement use was assessed using 7-d weighed food records. Blood values of folate, red blood cell (RBC) folate, riboflavin (using erythrocyte glutathione reductase activity coefficient [EGRAC]), B-12 and mean cell volume (MCV) were determined. There were no differences among groups for any variables using ANOVA. RA Active RA Sed. Control Active Control Sed. EGRAC 1.01±0.16 0.95±0.09 0.99±0.10 1.00±0.13 Folate (ng/ml) 16.1±6.7 14.3±7.6 12.2±7.6 14.1±5.3 RBC Folate 494±164 385±158 375±115 467±128 B12 (pg/ml) 632±290 692±396 648±461 602±377 MCV (fl) 95±6 92±6 90±5 93±4 In subjects not using a B-complex supplement (28%), one RA active subject had poor status for folate, B-12 and riboflavin. Due to high supplement use it is difficult to determine if activity and RA alter nutritional status.

Original languageEnglish (US)
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

Fingerprint

rheumatoid arthritis
Riboflavin
vitamin B12
Vitamin B 12
riboflavin
Folic Acid
folic acid
Rheumatoid Arthritis
Blood
Glutathione Reductase
Activity coefficients
Nutrition
erythrocytes
Erythrocytes
Erythrocyte Indices
glutathione-disulfide reductase
Analysis of variance (ANOVA)
Fats
Cells
food records

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Folate, vitamin B-12 and riboflavin status of active and sedentary elderly women with Rheumatoid Arthritis (RA). / Woolf, Kathleen; Manore, M. M.; Matt, K. S.

In: FASEB Journal, Vol. 12, No. 5, 20.03.1998.

Research output: Contribution to journalArticle

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