Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

Rachel P. Abrams, William L. Carroll, Keith Woerpel

Research output: Contribution to journalArticle

Abstract

A 1,2-dioxolane (FINO2) was identified as a lead compound from a screen of organic peroxides. FINO2 does not induce apoptosis, but instead initiates ferroptosis, an iron-dependent, oxidative cell death pathway. Few compounds are known to induce primarily ferroptosis. In contrast to the perceived instability of peroxides, FINO2 was found to be thermally stable to at least 150 °C. FINO2 was more potent in cancer cells than nonmalignant cells of the same type. One of the enantiomers was found to be more responsible for the observed activity.

Original languageEnglish (US)
Pages (from-to)1305-1312
Number of pages8
JournalACS Chemical Biology
Volume11
Issue number5
DOIs
StatePublished - May 20 2016

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Peroxides
Cells
Lead compounds
Enantiomers
Cell death
Neoplasms
Cell Death
Iron
Apoptosis
formal glycol
Lead

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine

Cite this

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells. / Abrams, Rachel P.; Carroll, William L.; Woerpel, Keith.

In: ACS Chemical Biology, Vol. 11, No. 5, 20.05.2016, p. 1305-1312.

Research output: Contribution to journalArticle

Abrams, Rachel P. ; Carroll, William L. ; Woerpel, Keith. / Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells. In: ACS Chemical Biology. 2016 ; Vol. 11, No. 5. pp. 1305-1312.
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