Fear-related activity in subgenual anterior cingulate differs between men and women

Tracy Butler, Hong Pan, Jane Epstein, Xenia Protopopescu, Oliver Tuescher, Martin Goldstein, Marylene Cloitre, Yihong Yang, Elizabeth Phelps, Jack Gorman, Joseph Ledoux, Emily Stern, David Silbersweig

Research output: Contribution to journalArticle

Abstract

Functional magnetic resonance imaging in association with an instructed fear/anticipatory anxiety paradigm was used to explore sex differences in the human fear response. During anticipation of mild electrodermal stimulation, women, as compared with men, demonstrated increased activity in the subgenual anterior cingulate cortex and functionally related regions of the insula and brainstem. The subgenual anterior cingulate cortex is a region critical for emotional control implicated in the pathogenesis of psychiatric disease. Present findings suggest a contributory neural substrate for the greater susceptibility of women to anxiety and affective disorders, and emphasize the importance of considering participant sex when designing and interpreting functional neuroimaging studies.

Original languageEnglish (US)
Pages (from-to)1233-1236
Number of pages4
JournalNeuroReport
Volume16
Issue number11
DOIs
StatePublished - Aug 1 2005

Fingerprint

Gyrus Cinguli
Fear
Functional Neuroimaging
Anxiety Disorders
Mood Disorders
Sex Characteristics
Brain Stem
Psychiatry
Anxiety
Magnetic Resonance Imaging

Keywords

  • Anticipatory anxiety
  • Emotion
  • Functional magnetic resonance imaging
  • Instructed fear
  • Sex
  • Sex differences
  • Ventromedial prefrontal cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Butler, T., Pan, H., Epstein, J., Protopopescu, X., Tuescher, O., Goldstein, M., ... Silbersweig, D. (2005). Fear-related activity in subgenual anterior cingulate differs between men and women. NeuroReport, 16(11), 1233-1236. https://doi.org/10.1097/00001756-200508010-00020

Fear-related activity in subgenual anterior cingulate differs between men and women. / Butler, Tracy; Pan, Hong; Epstein, Jane; Protopopescu, Xenia; Tuescher, Oliver; Goldstein, Martin; Cloitre, Marylene; Yang, Yihong; Phelps, Elizabeth; Gorman, Jack; Ledoux, Joseph; Stern, Emily; Silbersweig, David.

In: NeuroReport, Vol. 16, No. 11, 01.08.2005, p. 1233-1236.

Research output: Contribution to journalArticle

Butler, T, Pan, H, Epstein, J, Protopopescu, X, Tuescher, O, Goldstein, M, Cloitre, M, Yang, Y, Phelps, E, Gorman, J, Ledoux, J, Stern, E & Silbersweig, D 2005, 'Fear-related activity in subgenual anterior cingulate differs between men and women', NeuroReport, vol. 16, no. 11, pp. 1233-1236. https://doi.org/10.1097/00001756-200508010-00020
Butler T, Pan H, Epstein J, Protopopescu X, Tuescher O, Goldstein M et al. Fear-related activity in subgenual anterior cingulate differs between men and women. NeuroReport. 2005 Aug 1;16(11):1233-1236. https://doi.org/10.1097/00001756-200508010-00020
Butler, Tracy ; Pan, Hong ; Epstein, Jane ; Protopopescu, Xenia ; Tuescher, Oliver ; Goldstein, Martin ; Cloitre, Marylene ; Yang, Yihong ; Phelps, Elizabeth ; Gorman, Jack ; Ledoux, Joseph ; Stern, Emily ; Silbersweig, David. / Fear-related activity in subgenual anterior cingulate differs between men and women. In: NeuroReport. 2005 ; Vol. 16, No. 11. pp. 1233-1236.
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