Fatalities associated with the 2009 H1N1 influenza a virus in New York City

Ellen H. Lee, Charles Wu, Elsie U. Lee, Alaina Stoute, Heather Hanson, Heather A. Cook, Beth Nivin, Annie D. Fine, Bonnie D. Kerker, Scott A. Harper, Marcelle C. Layton, Sharon Balter, Susan Anderson, Jennifer Baumgartner, Jane Bedell, Elizabeth Begier, Diana Berger, Mitzie Blanc, Brooke Bregman, Sekai Chideya & 26 others Kinga Cieloszyk, Paula Del Rosso, Catherine Dentinger, Jacqueline Ehrlich, Bruce Gutelius, Tiffany Harris, Charu Jain, Melinda Jenkins, Lucretia Jones, Ram Koppaka, Melissa Marx, Maria Cecilia Mosquera, Trang Nguyen, Carolyn Olson, Douglas Proops, Kristen Semanision, Meredith Slopen, Catherine Stayton, Anafidelia Tavares, Nailah Thompson, Lorna Thorpe, Benjamin Tsoi, Elaine Vernetti, Don Weiss, Meredith Welch, Melissa Wong

Research output: Contribution to journalArticle

Abstract

Background. When the 2009 H1N1 influenza A virus emerged in the United States, epidemiologic and clinical information about severe and fatal cases was limited. We report the first 47 fatal cases of 2009 H1N1 influenza in New York City. Methods. The New York City Department of Health and Mental Hygiene conducted enhanced surveillance for hospitalizations and deaths associated with 2009 H1N1 influenza A virus. We collected basic demographic and clinical information for all patients who died and compared abstracted data from medical records for a sample of hospitalized patients who died and hospitalized patients who survived. Results. From 24 April through 1 July 2009, 47 confirmed fatal cases of 2009 H1N1 influenza were reported to the New York City Department of Health and Mental Hygiene. Most decedents (60%) were ages 18-49 years, and only 4% were aged 3*65 years. Many (79%) had underlying risk conditions for severe seasonal influenza, and 58% were obese according to their body mass index. Thirteen (28%) had evidence of invasive bacterial coinfection. Approximately 50% of the decedents had developed acute respiratory distress syndrome. Among all hospitalized patients, decedents had presented for hospitalization later (median, 3 vs 2 days after illness onset; P<.05) and received oseltamivir later (median, 6.5 vs 3 days; P<.01) than surviving patients. Hospitalized patients who died were less likely to have received oseltamivir within 2 days of hospitalization than hospitalized patients who survived (61% vs 96%; P<.01). Conclusions. With community-wide transmission of 2009 H1N1 influenza A virus, timely medical care and antiviral therapy should be considered for patients with severe influenza-like illness or with underlying risk conditions for complications from influenza.

Original languageEnglish (US)
Pages (from-to)1498-1504
Number of pages7
JournalClinical Infectious Diseases
Volume50
Issue number11
DOIs
StatePublished - Jun 1 2010

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H1N1 Subtype Influenza A Virus
Orthomyxoviridae
Human Influenza
Influenza A virus
Oseltamivir
Hospitalization
Mental Health
Sick Leave
Adult Respiratory Distress Syndrome
Health
Coinfection
Medical Records
Antiviral Agents
Body Mass Index
Demography

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Lee, E. H., Wu, C., Lee, E. U., Stoute, A., Hanson, H., Cook, H. A., ... Wong, M. (2010). Fatalities associated with the 2009 H1N1 influenza a virus in New York City. Clinical Infectious Diseases, 50(11), 1498-1504. https://doi.org/10.1086/652446

Fatalities associated with the 2009 H1N1 influenza a virus in New York City. / Lee, Ellen H.; Wu, Charles; Lee, Elsie U.; Stoute, Alaina; Hanson, Heather; Cook, Heather A.; Nivin, Beth; Fine, Annie D.; Kerker, Bonnie D.; Harper, Scott A.; Layton, Marcelle C.; Balter, Sharon; Anderson, Susan; Baumgartner, Jennifer; Bedell, Jane; Begier, Elizabeth; Berger, Diana; Blanc, Mitzie; Bregman, Brooke; Chideya, Sekai; Cieloszyk, Kinga; Rosso, Paula Del; Dentinger, Catherine; Ehrlich, Jacqueline; Gutelius, Bruce; Harris, Tiffany; Jain, Charu; Jenkins, Melinda; Jones, Lucretia; Koppaka, Ram; Marx, Melissa; Mosquera, Maria Cecilia; Nguyen, Trang; Olson, Carolyn; Proops, Douglas; Semanision, Kristen; Slopen, Meredith; Stayton, Catherine; Tavares, Anafidelia; Thompson, Nailah; Thorpe, Lorna; Tsoi, Benjamin; Vernetti, Elaine; Weiss, Don; Welch, Meredith; Wong, Melissa.

In: Clinical Infectious Diseases, Vol. 50, No. 11, 01.06.2010, p. 1498-1504.

Research output: Contribution to journalArticle

Lee, EH, Wu, C, Lee, EU, Stoute, A, Hanson, H, Cook, HA, Nivin, B, Fine, AD, Kerker, BD, Harper, SA, Layton, MC, Balter, S, Anderson, S, Baumgartner, J, Bedell, J, Begier, E, Berger, D, Blanc, M, Bregman, B, Chideya, S, Cieloszyk, K, Rosso, PD, Dentinger, C, Ehrlich, J, Gutelius, B, Harris, T, Jain, C, Jenkins, M, Jones, L, Koppaka, R, Marx, M, Mosquera, MC, Nguyen, T, Olson, C, Proops, D, Semanision, K, Slopen, M, Stayton, C, Tavares, A, Thompson, N, Thorpe, L, Tsoi, B, Vernetti, E, Weiss, D, Welch, M & Wong, M 2010, 'Fatalities associated with the 2009 H1N1 influenza a virus in New York City', Clinical Infectious Diseases, vol. 50, no. 11, pp. 1498-1504. https://doi.org/10.1086/652446
Lee EH, Wu C, Lee EU, Stoute A, Hanson H, Cook HA et al. Fatalities associated with the 2009 H1N1 influenza a virus in New York City. Clinical Infectious Diseases. 2010 Jun 1;50(11):1498-1504. https://doi.org/10.1086/652446
Lee, Ellen H. ; Wu, Charles ; Lee, Elsie U. ; Stoute, Alaina ; Hanson, Heather ; Cook, Heather A. ; Nivin, Beth ; Fine, Annie D. ; Kerker, Bonnie D. ; Harper, Scott A. ; Layton, Marcelle C. ; Balter, Sharon ; Anderson, Susan ; Baumgartner, Jennifer ; Bedell, Jane ; Begier, Elizabeth ; Berger, Diana ; Blanc, Mitzie ; Bregman, Brooke ; Chideya, Sekai ; Cieloszyk, Kinga ; Rosso, Paula Del ; Dentinger, Catherine ; Ehrlich, Jacqueline ; Gutelius, Bruce ; Harris, Tiffany ; Jain, Charu ; Jenkins, Melinda ; Jones, Lucretia ; Koppaka, Ram ; Marx, Melissa ; Mosquera, Maria Cecilia ; Nguyen, Trang ; Olson, Carolyn ; Proops, Douglas ; Semanision, Kristen ; Slopen, Meredith ; Stayton, Catherine ; Tavares, Anafidelia ; Thompson, Nailah ; Thorpe, Lorna ; Tsoi, Benjamin ; Vernetti, Elaine ; Weiss, Don ; Welch, Meredith ; Wong, Melissa. / Fatalities associated with the 2009 H1N1 influenza a virus in New York City. In: Clinical Infectious Diseases. 2010 ; Vol. 50, No. 11. pp. 1498-1504.
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abstract = "Background. When the 2009 H1N1 influenza A virus emerged in the United States, epidemiologic and clinical information about severe and fatal cases was limited. We report the first 47 fatal cases of 2009 H1N1 influenza in New York City. Methods. The New York City Department of Health and Mental Hygiene conducted enhanced surveillance for hospitalizations and deaths associated with 2009 H1N1 influenza A virus. We collected basic demographic and clinical information for all patients who died and compared abstracted data from medical records for a sample of hospitalized patients who died and hospitalized patients who survived. Results. From 24 April through 1 July 2009, 47 confirmed fatal cases of 2009 H1N1 influenza were reported to the New York City Department of Health and Mental Hygiene. Most decedents (60{\%}) were ages 18-49 years, and only 4{\%} were aged 3*65 years. Many (79{\%}) had underlying risk conditions for severe seasonal influenza, and 58{\%} were obese according to their body mass index. Thirteen (28{\%}) had evidence of invasive bacterial coinfection. Approximately 50{\%} of the decedents had developed acute respiratory distress syndrome. Among all hospitalized patients, decedents had presented for hospitalization later (median, 3 vs 2 days after illness onset; P<.05) and received oseltamivir later (median, 6.5 vs 3 days; P<.01) than surviving patients. Hospitalized patients who died were less likely to have received oseltamivir within 2 days of hospitalization than hospitalized patients who survived (61{\%} vs 96{\%}; P<.01). Conclusions. With community-wide transmission of 2009 H1N1 influenza A virus, timely medical care and antiviral therapy should be considered for patients with severe influenza-like illness or with underlying risk conditions for complications from influenza.",
author = "Lee, {Ellen H.} and Charles Wu and Lee, {Elsie U.} and Alaina Stoute and Heather Hanson and Cook, {Heather A.} and Beth Nivin and Fine, {Annie D.} and Kerker, {Bonnie D.} and Harper, {Scott A.} and Layton, {Marcelle C.} and Sharon Balter and Susan Anderson and Jennifer Baumgartner and Jane Bedell and Elizabeth Begier and Diana Berger and Mitzie Blanc and Brooke Bregman and Sekai Chideya and Kinga Cieloszyk and Rosso, {Paula Del} and Catherine Dentinger and Jacqueline Ehrlich and Bruce Gutelius and Tiffany Harris and Charu Jain and Melinda Jenkins and Lucretia Jones and Ram Koppaka and Melissa Marx and Mosquera, {Maria Cecilia} and Trang Nguyen and Carolyn Olson and Douglas Proops and Kristen Semanision and Meredith Slopen and Catherine Stayton and Anafidelia Tavares and Nailah Thompson and Lorna Thorpe and Benjamin Tsoi and Elaine Vernetti and Don Weiss and Meredith Welch and Melissa Wong",
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T1 - Fatalities associated with the 2009 H1N1 influenza a virus in New York City

AU - Lee, Ellen H.

AU - Wu, Charles

AU - Lee, Elsie U.

AU - Stoute, Alaina

AU - Hanson, Heather

AU - Cook, Heather A.

AU - Nivin, Beth

AU - Fine, Annie D.

AU - Kerker, Bonnie D.

AU - Harper, Scott A.

AU - Layton, Marcelle C.

AU - Balter, Sharon

AU - Anderson, Susan

AU - Baumgartner, Jennifer

AU - Bedell, Jane

AU - Begier, Elizabeth

AU - Berger, Diana

AU - Blanc, Mitzie

AU - Bregman, Brooke

AU - Chideya, Sekai

AU - Cieloszyk, Kinga

AU - Rosso, Paula Del

AU - Dentinger, Catherine

AU - Ehrlich, Jacqueline

AU - Gutelius, Bruce

AU - Harris, Tiffany

AU - Jain, Charu

AU - Jenkins, Melinda

AU - Jones, Lucretia

AU - Koppaka, Ram

AU - Marx, Melissa

AU - Mosquera, Maria Cecilia

AU - Nguyen, Trang

AU - Olson, Carolyn

AU - Proops, Douglas

AU - Semanision, Kristen

AU - Slopen, Meredith

AU - Stayton, Catherine

AU - Tavares, Anafidelia

AU - Thompson, Nailah

AU - Thorpe, Lorna

AU - Tsoi, Benjamin

AU - Vernetti, Elaine

AU - Weiss, Don

AU - Welch, Meredith

AU - Wong, Melissa

PY - 2010/6/1

Y1 - 2010/6/1

N2 - Background. When the 2009 H1N1 influenza A virus emerged in the United States, epidemiologic and clinical information about severe and fatal cases was limited. We report the first 47 fatal cases of 2009 H1N1 influenza in New York City. Methods. The New York City Department of Health and Mental Hygiene conducted enhanced surveillance for hospitalizations and deaths associated with 2009 H1N1 influenza A virus. We collected basic demographic and clinical information for all patients who died and compared abstracted data from medical records for a sample of hospitalized patients who died and hospitalized patients who survived. Results. From 24 April through 1 July 2009, 47 confirmed fatal cases of 2009 H1N1 influenza were reported to the New York City Department of Health and Mental Hygiene. Most decedents (60%) were ages 18-49 years, and only 4% were aged 3*65 years. Many (79%) had underlying risk conditions for severe seasonal influenza, and 58% were obese according to their body mass index. Thirteen (28%) had evidence of invasive bacterial coinfection. Approximately 50% of the decedents had developed acute respiratory distress syndrome. Among all hospitalized patients, decedents had presented for hospitalization later (median, 3 vs 2 days after illness onset; P<.05) and received oseltamivir later (median, 6.5 vs 3 days; P<.01) than surviving patients. Hospitalized patients who died were less likely to have received oseltamivir within 2 days of hospitalization than hospitalized patients who survived (61% vs 96%; P<.01). Conclusions. With community-wide transmission of 2009 H1N1 influenza A virus, timely medical care and antiviral therapy should be considered for patients with severe influenza-like illness or with underlying risk conditions for complications from influenza.

AB - Background. When the 2009 H1N1 influenza A virus emerged in the United States, epidemiologic and clinical information about severe and fatal cases was limited. We report the first 47 fatal cases of 2009 H1N1 influenza in New York City. Methods. The New York City Department of Health and Mental Hygiene conducted enhanced surveillance for hospitalizations and deaths associated with 2009 H1N1 influenza A virus. We collected basic demographic and clinical information for all patients who died and compared abstracted data from medical records for a sample of hospitalized patients who died and hospitalized patients who survived. Results. From 24 April through 1 July 2009, 47 confirmed fatal cases of 2009 H1N1 influenza were reported to the New York City Department of Health and Mental Hygiene. Most decedents (60%) were ages 18-49 years, and only 4% were aged 3*65 years. Many (79%) had underlying risk conditions for severe seasonal influenza, and 58% were obese according to their body mass index. Thirteen (28%) had evidence of invasive bacterial coinfection. Approximately 50% of the decedents had developed acute respiratory distress syndrome. Among all hospitalized patients, decedents had presented for hospitalization later (median, 3 vs 2 days after illness onset; P<.05) and received oseltamivir later (median, 6.5 vs 3 days; P<.01) than surviving patients. Hospitalized patients who died were less likely to have received oseltamivir within 2 days of hospitalization than hospitalized patients who survived (61% vs 96%; P<.01). Conclusions. With community-wide transmission of 2009 H1N1 influenza A virus, timely medical care and antiviral therapy should be considered for patients with severe influenza-like illness or with underlying risk conditions for complications from influenza.

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DO - 10.1086/652446

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