Faster voltage-dependent activation of Na+ channels in growth cones versus somata of neuroblastoma N1E-115 cells

Jing Zhang, Leslie M. Loew, Robert Davidson

Research output: Contribution to journalArticle

Abstract

Kinetics of voltage-gated ionic channels fundamentally reflect the response of the channels to local electric fields. In this report cell- attached patch-clamp studies reveal that the voltage-dependent activation rate of sodium channels residing in the growth cone membrane differs from that of soma sodium channels in differentiating N1E-115 neuroblastoma cells. Because other electrophysiological properties of these channels do not differ, this finding may be a reflection of the difference in intramembrane electric field in these two regions of the cell. This represents a new mechanism for channels to attain a range of activities both within and between cells.

Original languageEnglish (US)
Pages (from-to)2501-2508
Number of pages8
JournalBiophysical Journal
Volume71
Issue number5
StatePublished - Nov 1996

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Growth Cones
Carisoprodol
Neuroblastoma
Sodium Channels
Ion Channels
Membranes

ASJC Scopus subject areas

  • Biophysics

Cite this

Faster voltage-dependent activation of Na+ channels in growth cones versus somata of neuroblastoma N1E-115 cells. / Zhang, Jing; Loew, Leslie M.; Davidson, Robert.

In: Biophysical Journal, Vol. 71, No. 5, 11.1996, p. 2501-2508.

Research output: Contribution to journalArticle

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