Abstract
Paranemic crossover (PX) DNA motifs were designed and used for self-assembly of two dimensional lattices. The PX motifs tested include overwound and underwound ones, and different forms of self-assembled two-dimensional (2D) lattices were generated, demonstrating the correlation between the helical torsional strain within the system and the quality of the lattice formed. Relief of the torsional strain by adjusting the number of base pairs in the JX region adjacent to the PX motifs, facilitates and optimizes DNA self-assembly, which leads to 2D lattices of greater uniformity and higher yield. This study demonstrated that the helical relationship among DNA building blocks is a critical factor for the tile-based self-assembly of large nanostructures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 465-469 |
| Number of pages | 5 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2017 |
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ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
Cite this
Facilitation of DNA self-assembly by relieving the torsional strains between building blocks. / Shen, Weili; Liu, Qing; Ding, Baoquan; Zhu, Changqing; Shen, Zhiyong; Seeman, Nadrian.
In: Organic and Biomolecular Chemistry, Vol. 15, No. 2, 2017, p. 465-469.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Facilitation of DNA self-assembly by relieving the torsional strains between building blocks
AU - Shen, Weili
AU - Liu, Qing
AU - Ding, Baoquan
AU - Zhu, Changqing
AU - Shen, Zhiyong
AU - Seeman, Nadrian
PY - 2017
Y1 - 2017
N2 - Paranemic crossover (PX) DNA motifs were designed and used for self-assembly of two dimensional lattices. The PX motifs tested include overwound and underwound ones, and different forms of self-assembled two-dimensional (2D) lattices were generated, demonstrating the correlation between the helical torsional strain within the system and the quality of the lattice formed. Relief of the torsional strain by adjusting the number of base pairs in the JX region adjacent to the PX motifs, facilitates and optimizes DNA self-assembly, which leads to 2D lattices of greater uniformity and higher yield. This study demonstrated that the helical relationship among DNA building blocks is a critical factor for the tile-based self-assembly of large nanostructures.
AB - Paranemic crossover (PX) DNA motifs were designed and used for self-assembly of two dimensional lattices. The PX motifs tested include overwound and underwound ones, and different forms of self-assembled two-dimensional (2D) lattices were generated, demonstrating the correlation between the helical torsional strain within the system and the quality of the lattice formed. Relief of the torsional strain by adjusting the number of base pairs in the JX region adjacent to the PX motifs, facilitates and optimizes DNA self-assembly, which leads to 2D lattices of greater uniformity and higher yield. This study demonstrated that the helical relationship among DNA building blocks is a critical factor for the tile-based self-assembly of large nanostructures.
UR - http://www.scopus.com/inward/record.url?scp=85008881493&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008881493&partnerID=8YFLogxK
U2 - 10.1039/C6OB02281B
DO - 10.1039/C6OB02281B
M3 - Article
VL - 15
SP - 465
EP - 469
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
SN - 1477-0520
IS - 2
ER -