Face-Discriminating Dissolution Kinetics of Furosemide Single Crystals: In Situ Three-Dimensional Multi-Microscopy and Modeling

Maria Adobes-Vidal, Faduma M. Maddar, Dmitry Momotenko, Leslie P. Hughes, Stephen A C Wren, Laura N. Poloni, Michael Ward, Patrick R. Unwin

Research output: Contribution to journalArticle

Abstract

A versatile in situ multi-microscopy approach to study the dissolution kinetics of single crystals is described, using the loop diuretic drug furosemide as a testbed to demonstrate the utility of the approach. Using optical microscopy and scanning ion-conductance microscopy in combination, the dissolution rate of individual crystallographically independent crystal faces can be measured quantitatively while providing a direct visualization of the evolution of crystal morphology in real time in three dimensions. Finite element method models using experimental data enables quantitative analysis of dissolution fluxes for individual faces and determination of the limiting process - mass transport or interfacial kinetics - that regulates dissolution. A key feature of the approach is that isolated crystals (typically <60 μm largest characteristic dimension) in solution during dissolution experience high and well-defined diffusion rates. The ability to obtain this quantitative information for individual crystal faces suggests a pathway to understanding crystal dissolution at the molecular level and regulating bioavailability, for example, through manipulation of crystal morphology.

Original languageEnglish (US)
Pages (from-to)4421-4429
Number of pages9
JournalCrystal Growth and Design
Volume16
Issue number8
DOIs
StatePublished - Aug 3 2016

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Furosemide
Microscopic examination
dissolving
Dissolution
Single crystals
microscopy
Crystals
Kinetics
single crystals
kinetics
crystal morphology
crystals
diuretics
Sodium Potassium Chloride Symporter Inhibitors
bioavailability
Testbeds
quantitative analysis
Optical microscopy
manipulators
finite element method

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Adobes-Vidal, M., Maddar, F. M., Momotenko, D., Hughes, L. P., Wren, S. A. C., Poloni, L. N., ... Unwin, P. R. (2016). Face-Discriminating Dissolution Kinetics of Furosemide Single Crystals: In Situ Three-Dimensional Multi-Microscopy and Modeling. Crystal Growth and Design, 16(8), 4421-4429. https://doi.org/10.1021/acs.cgd.6b00543

Face-Discriminating Dissolution Kinetics of Furosemide Single Crystals : In Situ Three-Dimensional Multi-Microscopy and Modeling. / Adobes-Vidal, Maria; Maddar, Faduma M.; Momotenko, Dmitry; Hughes, Leslie P.; Wren, Stephen A C; Poloni, Laura N.; Ward, Michael; Unwin, Patrick R.

In: Crystal Growth and Design, Vol. 16, No. 8, 03.08.2016, p. 4421-4429.

Research output: Contribution to journalArticle

Adobes-Vidal, Maria ; Maddar, Faduma M. ; Momotenko, Dmitry ; Hughes, Leslie P. ; Wren, Stephen A C ; Poloni, Laura N. ; Ward, Michael ; Unwin, Patrick R. / Face-Discriminating Dissolution Kinetics of Furosemide Single Crystals : In Situ Three-Dimensional Multi-Microscopy and Modeling. In: Crystal Growth and Design. 2016 ; Vol. 16, No. 8. pp. 4421-4429.
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