Extinction-Reconsolidation boundaries

Key to persistent attenuation of fear memories

Marie H. Monfils, Kiriana K. Cowansage, Eric Klann, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Dysregulation of the fear system is at the core of many psychiatric disorders. Much progress has been made in uncovering the neural basis of fear learning through studies in which associative emotional memories are formed by pairing an initially neutral stimulus (conditioned stimulus, CS; e.g., a tone) to an unconditioned stimulus (US; e.g., a shock). Despite recent advances, the question of how to persistently weaken aversive CS-US associations, or dampen traumatic memories in pathological cases, remains a major dilemma. Two paradigms (blockade of reconsolidation and extinction) have been used in the laboratory to reduce acquired fear. Unfortunately, their clinical efficacy is limited: Reconsolidation blockade typically requires potentially toxic drugs, and extinction is not permanent. Here, we describe a behavioral design in which a fear memory in rats is destabilized and reinterpreted as safe by presenting an isolated retrieval trial before an extinction session. This procedure permanently attenuates the fear memory without the use of drugs.

Original languageEnglish (US)
Pages (from-to)951-955
Number of pages5
JournalScience
Volume324
Issue number5929
DOIs
StatePublished - May 15 2009

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Fear
Poisons
Pharmaceutical Preparations
Psychiatry
Shock
Psychological Extinction
Learning

ASJC Scopus subject areas

  • General
  • Medicine(all)

Cite this

Extinction-Reconsolidation boundaries : Key to persistent attenuation of fear memories. / Monfils, Marie H.; Cowansage, Kiriana K.; Klann, Eric; Ledoux, Joseph.

In: Science, Vol. 324, No. 5929, 15.05.2009, p. 951-955.

Research output: Contribution to journalArticle

Monfils, Marie H. ; Cowansage, Kiriana K. ; Klann, Eric ; Ledoux, Joseph. / Extinction-Reconsolidation boundaries : Key to persistent attenuation of fear memories. In: Science. 2009 ; Vol. 324, No. 5929. pp. 951-955.
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