Expression profile of Ldh-a in the developing rat Rattus norvegicus testis suggests regulation at the translational level

Kourosh Salehi-Ashtiani, Erwin Goldberg

Research output: Contribution to journalArticle

Abstract

Expression of Ldh-a and Ldh-c mRNAs was examined in the rat testis. The mRNA levels of both Ldh-a and Ldh-c increase during testicular maturation. In the adult testis, Ldh-a mRNA is expressed maximally in primary spermatocytes. Comparison of the Ldh-a mRNA expression profile with its translation product suggests that this gene is translationally down-regulated during spermatogenesis.

Original languageEnglish (US)
Pages (from-to)623-627
Number of pages5
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume110
Issue number3
DOIs
StatePublished - Jan 1 1995

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Testis
Rats
Messenger RNA
Spermatocytes
Spermatogenesis
Genes

Keywords

  • Gene expression
  • Isozyme switching
  • Lactate dehydrogenase
  • Ldh-c, Ldh-a
  • Puberty
  • Spermatogenesis
  • Translational regulation

ASJC Scopus subject areas

  • Biochemistry
  • Physiology

Cite this

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abstract = "Expression of Ldh-a and Ldh-c mRNAs was examined in the rat testis. The mRNA levels of both Ldh-a and Ldh-c increase during testicular maturation. In the adult testis, Ldh-a mRNA is expressed maximally in primary spermatocytes. Comparison of the Ldh-a mRNA expression profile with its translation product suggests that this gene is translationally down-regulated during spermatogenesis.",
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AB - Expression of Ldh-a and Ldh-c mRNAs was examined in the rat testis. The mRNA levels of both Ldh-a and Ldh-c increase during testicular maturation. In the adult testis, Ldh-a mRNA is expressed maximally in primary spermatocytes. Comparison of the Ldh-a mRNA expression profile with its translation product suggests that this gene is translationally down-regulated during spermatogenesis.

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KW - Spermatogenesis

KW - Translational regulation

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