Expression of IL-12 receptor by neurons

Derek D C Ireland, Carol Shoshkes Reiss

Research output: Contribution to journalArticle

Abstract

Interleukin (IL)-12, a key cytokine bridging innate and acquired immunity, is efficacious in enhancing recovery from experimental vesicular stomatitis virus (VSV) infection of the mouse central nervous system (CNS). This response is associated with the upregulation of neuronal nitric oxide synthase (NOS-1), independent of IFN-γ and TNF-α. We hypothesized that neurons may respond directly IL-12. Our data are consistent with the expression of a functional IL-12 receptor (IL-12R) by neurons in culture and this receptor-ligand interaction results in the induction of an innate antiviral immune response. N18 cells, which did not express IL-12Rβ2 were transfected with the IL-12Rβ2 receptor gene; Koch's postulates were fulfilled, as clones derived from this transfection were reconstituted for IL-12 responsiveness.

Original languageEnglish (US)
Pages (from-to)411-422
Number of pages12
JournalViral Immunology
Volume17
Issue number3
DOIs
StatePublished - 2004

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Interleukin-12 Receptors
Interleukin-12
Neurons
Innate Immunity
Interleukin Receptors
Nitric Oxide Synthase Type I
Vesicular Stomatitis
Interleukins
Adaptive Immunity
Virus Diseases
Antiviral Agents
Transfection
Up-Regulation
Central Nervous System
Clone Cells
Cytokines
Ligands
Genes

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Expression of IL-12 receptor by neurons. / Ireland, Derek D C; Reiss, Carol Shoshkes.

In: Viral Immunology, Vol. 17, No. 3, 2004, p. 411-422.

Research output: Contribution to journalArticle

Ireland, Derek D C ; Reiss, Carol Shoshkes. / Expression of IL-12 receptor by neurons. In: Viral Immunology. 2004 ; Vol. 17, No. 3. pp. 411-422.
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