Exploiting gene expression variation to capture gene-environment interactions for disease

Youssef Idaghdhour, Philip Awadalla

    Research output: Contribution to journalArticle

    Abstract

    Gene-environment interactions have long been recognized as a fundamental concept in evolutionary, quantitative, and medical genetics. In the genomics era, study of how environment and genome interact to shape gene expression variation is relevant to understanding the genetic architecture of complex phenotypes. While genetic analysis of gene expression variation focused on main effects, little is known about the extent of interaction effects implicating regulatory variants and their consequences on transcriptional variation. Here we survey the current state of the concept of transcriptional gene-environment interactions and discuss its utility for mapping disease phenotypes in light of the insights gained from genome-wide association studies of gene expression.

    Original languageEnglish (US)
    Article numberArticle 228
    JournalFrontiers in Genetics
    Volume4
    Issue numberMAY
    DOIs
    StatePublished - Sep 11 2013

    Fingerprint

    Gene-Environment Interaction
    Gene Expression
    Phenotype
    Genome-Wide Association Study
    Medical Genetics
    Genomics
    Genome

    Keywords

    • eQTL
    • eSNP
    • Gene-environment interactions
    • Transcriptome

    ASJC Scopus subject areas

    • Molecular Medicine
    • Genetics
    • Genetics(clinical)

    Cite this

    Exploiting gene expression variation to capture gene-environment interactions for disease. / Idaghdhour, Youssef; Awadalla, Philip.

    In: Frontiers in Genetics, Vol. 4, No. MAY, Article 228, 11.09.2013.

    Research output: Contribution to journalArticle

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