Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers

Sean P. Deeny, David Poeppel, Jo B. Zimmerman, Stephen M. Roth, Josef Brandauer, Sarah Witkowski, Joseph W. Hearn, Andrew T. Ludlow, José L. Contreras-Vidal, Jason Brandt, Bradley D. Hatfield

Research output: Contribution to journalArticle

Abstract

Performance on the Sternberg working memory task, and MEG cortical response on a variation of the Sternberg task were examined in middle-aged carriers and non-carriers of the APOE ε4 allele. Physical activity was also assessed to examine whether exercise level modifies the relationship between APOE genotype and neurocognitive function. Regression revealed that high physical activity was associated with faster RT in the six- and eight-letter conditions of the Sternberg in ε4 carriers, but not in the non-carriers after controlling for age, gender, and education (N = 54). Furthermore, the MEG analysis revealed that sedentary ε4 carriers exhibited lower right temporal lobe activation on matching probe trials relative to high-active ε4 carriers, while physical activity did not distinguish non-carriers (N = 23). The M170 peak was identified as a potential marker for pre-clinical decline as ε4 carriers exhibited longer M170 latency, and highly physically active participants exhibited greater M170 amplitude to matching probe trials.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalBiological Psychology
Volume78
Issue number2
DOIs
StatePublished - May 2008

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Temporal Lobe
Short-Term Memory
Biomarkers
Alleles
Genotype
Education

Keywords

  • APOE
  • Exercise
  • M170
  • MEG
  • Working Memory

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neuropsychology and Physiological Psychology

Cite this

Exercise, APOE, and working memory : MEG and behavioral evidence for benefit of exercise in epsilon4 carriers. / Deeny, Sean P.; Poeppel, David; Zimmerman, Jo B.; Roth, Stephen M.; Brandauer, Josef; Witkowski, Sarah; Hearn, Joseph W.; Ludlow, Andrew T.; Contreras-Vidal, José L.; Brandt, Jason; Hatfield, Bradley D.

In: Biological Psychology, Vol. 78, No. 2, 05.2008, p. 179-187.

Research output: Contribution to journalArticle

Deeny, SP, Poeppel, D, Zimmerman, JB, Roth, SM, Brandauer, J, Witkowski, S, Hearn, JW, Ludlow, AT, Contreras-Vidal, JL, Brandt, J & Hatfield, BD 2008, 'Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers', Biological Psychology, vol. 78, no. 2, pp. 179-187. https://doi.org/10.1016/j.biopsycho.2008.02.007
Deeny, Sean P. ; Poeppel, David ; Zimmerman, Jo B. ; Roth, Stephen M. ; Brandauer, Josef ; Witkowski, Sarah ; Hearn, Joseph W. ; Ludlow, Andrew T. ; Contreras-Vidal, José L. ; Brandt, Jason ; Hatfield, Bradley D. / Exercise, APOE, and working memory : MEG and behavioral evidence for benefit of exercise in epsilon4 carriers. In: Biological Psychology. 2008 ; Vol. 78, No. 2. pp. 179-187.
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