Evidence for an alteration of the tonotopic map in the gerbil cochlea during development

Dan Sanes, M. Merickel, E. W. Rubel

Research output: Contribution to journalArticle

Abstract

We have investigated developmental alterations in the tonotopic projection of the gerbil lateral superior olive. Single neurons were characterized in the frequency domain and the recording site marked with fast green. Transverse tissue sections form the auditory brainstem of each animal were visualized with a vido-equipped microscope, and the image was digitized for subsequent alignment. The three-dimensional display indicated little variation in the rostrocaudul axis, following us to collapse the data into a two-dimensional tonotopic map. The tonotopic map was found to change with age such that the characteristic frequency of neurons in a given anatomical location became successively higher during development. These results are consistent with the hypothesis that the place code gradually shifts in the developing cochlea.

Original languageEnglish (US)
Pages (from-to)436-444
Number of pages9
JournalJournal of Comparative Neurology
Volume279
Issue number3
StatePublished - 1989

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Gerbillinae
Cochlea
Neurons
Brain Stem
Superior Olivary Complex
Fast Green

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Evidence for an alteration of the tonotopic map in the gerbil cochlea during development. / Sanes, Dan; Merickel, M.; Rubel, E. W.

In: Journal of Comparative Neurology, Vol. 279, No. 3, 1989, p. 436-444.

Research output: Contribution to journalArticle

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