Evidence for a novel voltage-activated channel in the outer mitochondrial membrane

K. W. Kinnally, H. Tedeschi, C. A. Mannella

Research output: Contribution to journalArticle

Abstract

Patch-clamp studies of the outer mitochondrial membrane indicate a voltage-dependent increase in conductance for potentials positive relative to the exterior of the mitochondrion. The time course of the conductance changes is consistent with an activation of channels. Voltage pulse experiments suggest that the activation phenomenon corresponds to assembly of the channels from subunits with disassembly occurring after recovery of the original conductance. Effects of temperature and concanavalin A on the voltage-induced conductances are also consistent with a channel assembly model.

Original languageEnglish (US)
Pages (from-to)83-87
Number of pages5
JournalFEBS Letters
Volume226
Issue number1
DOIs
StatePublished - Dec 21 1987

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Keywords

  • Ion channel
  • Mitochondrial outer membrane
  • Patch clamp

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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