Evaluation of a low-temperature calcium phosphate particulate implant material: Physical-chemical properties and in vivo bone response

John L. Ricci, Norman C. Blumenthal, J. M. Spivak, H. Alexander

Research output: Contribution to journalArticle


A study was conducted to evaluate the osteoconductive ability of a particulate, low-temperature hydroxylapatite (HALT) material (OsteoGen; Impladent, Holliswood, NY). An implantable chamber model was used to determine the ability of this material to encourage bone ingrowth into channels lined with either roughsurfaced titanium or rough-surfaced plasma-sprayed hydroxylapatite. The HALT material increased bone ingrowth into the titanium-lined channels comparable with that in plasma-sprayed hydroxylapatite-coated channels. It was incorporated into ingrowing bone without intervening soft tissue, with the bone bonding directly to the material surface in much the same fashion as it bonds at the plasma-sprayed hydroxylapatite surface. Mechanical testing of the ingrown bone showed no weakness because particles were incorporated. At 12 weeks, the particles began to show signs of dissolution. It was concluded that the HALT material is a biocompatible, osteoconductive material that conducts bone ingrowth in much the same way as high-temperature particulate hydroxylapatite ceramics. This material has the additional desirable property of being slowly resorbable, a beneficial characteristic for many bone-filling applications.

Original languageEnglish (US)
Pages (from-to)969-978
Number of pages10
JournalJournal of Oral and Maxillofacial Surgery
Issue number9
StatePublished - Sep 1992


ASJC Scopus subject areas

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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