Ethnicity, body mass, and genome-wide data

Jason D. Boardman, Casey L. Blalock, Robin P. Corley, Michael C. Stallings, Benjamin W. Domingue, Matthew B. McQueen, Thomas J. Crowley, John K. Hewitt, Ying Lu, Samuel H. Field

Research output: Contribution to journalArticle

Abstract

This article combines social and genetic epidemiology to examine the influence of self-reported ethnicity on body mass index (BMI) among a sample of adolescents and young adults. We use genetic information from more than 5,000 single nucleotide polymorphisms in combination with principal components analysis to characterize population ancestry of individuals in this study. We show that non-Hispanic white and Mexican-American respondents differ significantly with respect to BMI and differ on the first principal component from the genetic data. This first component is positively associated with BMI and accounts for roughly 3% of the genetic variance in our sample. However, after controlling for this genetic measure, the observed ethnic differences in BMI remain large and statistically significant. This study demonstrates a parsimonious method to adjust for genetic differences among individual respondents that may contribute to observed differences in outcomes. In this case, adjusting for genetic background has no bearing on the influence of self-identified ethnicity.

Original languageEnglish (US)
Pages (from-to)123-136
Number of pages14
JournalBiodemography and Social Biology
Volume56
Issue number2
DOIs
StatePublished - 2010

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ethnicity
nationalities and ethnic groups
body mass
Body Mass Index
genome
Genome
body mass index
Molecular Epidemiology
Mexican Americans
ethnic differences
Principal Component Analysis
Individuality
Single Nucleotide Polymorphism
Young Adult
genetic variance
young adults
genetic background
single nucleotide polymorphism
epidemiology
ancestry

ASJC Scopus subject areas

  • Demography
  • Ecology, Evolution, Behavior and Systematics
  • Anthropology
  • Genetics

Cite this

Boardman, J. D., Blalock, C. L., Corley, R. P., Stallings, M. C., Domingue, B. W., McQueen, M. B., ... Field, S. H. (2010). Ethnicity, body mass, and genome-wide data. Biodemography and Social Biology, 56(2), 123-136. https://doi.org/10.1080/19485565.2010.524589

Ethnicity, body mass, and genome-wide data. / Boardman, Jason D.; Blalock, Casey L.; Corley, Robin P.; Stallings, Michael C.; Domingue, Benjamin W.; McQueen, Matthew B.; Crowley, Thomas J.; Hewitt, John K.; Lu, Ying; Field, Samuel H.

In: Biodemography and Social Biology, Vol. 56, No. 2, 2010, p. 123-136.

Research output: Contribution to journalArticle

Boardman, JD, Blalock, CL, Corley, RP, Stallings, MC, Domingue, BW, McQueen, MB, Crowley, TJ, Hewitt, JK, Lu, Y & Field, SH 2010, 'Ethnicity, body mass, and genome-wide data', Biodemography and Social Biology, vol. 56, no. 2, pp. 123-136. https://doi.org/10.1080/19485565.2010.524589
Boardman JD, Blalock CL, Corley RP, Stallings MC, Domingue BW, McQueen MB et al. Ethnicity, body mass, and genome-wide data. Biodemography and Social Biology. 2010;56(2):123-136. https://doi.org/10.1080/19485565.2010.524589
Boardman, Jason D. ; Blalock, Casey L. ; Corley, Robin P. ; Stallings, Michael C. ; Domingue, Benjamin W. ; McQueen, Matthew B. ; Crowley, Thomas J. ; Hewitt, John K. ; Lu, Ying ; Field, Samuel H. / Ethnicity, body mass, and genome-wide data. In: Biodemography and Social Biology. 2010 ; Vol. 56, No. 2. pp. 123-136.
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