Estimating neural sources from each time-frequency component of magnetoencephalographic data

Kensuke Sekihara, Srikantan S. Nagarajan, David Poeppel, Satoru Miyauchi, Norio Fujimaki, Hideaki Koizumi, Yasushi Miyashita

Research output: Contribution to journalArticle

Abstract

We have developed a method that incorporates the time-frequency characteristics of neural sources into magnetoencephalographic (MEG) source estimation. This method, referred to as the time-frequency multiple-signal- classification algorithm, allows the locations of neural sources to be estimated from any time-frequency region of interest. In this paper, we formulate the method based on the most general form of the quadratic time- frequency representations. We then apply it to two kinds of nonstationary MEG data: gamma-band (frequency range between 30-100 Hz) auditory activity data and spontaneous MEG data. Our method successfully detected the gamma-band source slightly medial to the N1m source location. The method was able to selectively localize sources for alpha-rhythm bursts at different locations. It also detected the mu-rhythm source from the alpha-rhythm-dominant MEG data that was measured with the subject's eyes closed. The results of these applications validate the effectiveness of the time-frequency MUSIC algorithm for selectively localizing sources having different time-frequency signatures.

Original languageEnglish (US)
Pages (from-to)642-653
Number of pages12
JournalIEEE Transactions on Biomedical Engineering
Volume47
Issue number5
DOIs
StatePublished - 2000

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Bioelectric potentials
Frequency bands

Keywords

  • Biomagnetism
  • Biomedical signal processing
  • Functional brain imaging
  • Inverse problems
  • Time-frequency analysis

ASJC Scopus subject areas

  • Biomedical Engineering

Cite this

Estimating neural sources from each time-frequency component of magnetoencephalographic data. / Sekihara, Kensuke; Nagarajan, Srikantan S.; Poeppel, David; Miyauchi, Satoru; Fujimaki, Norio; Koizumi, Hideaki; Miyashita, Yasushi.

In: IEEE Transactions on Biomedical Engineering, Vol. 47, No. 5, 2000, p. 642-653.

Research output: Contribution to journalArticle

Sekihara, K, Nagarajan, SS, Poeppel, D, Miyauchi, S, Fujimaki, N, Koizumi, H & Miyashita, Y 2000, 'Estimating neural sources from each time-frequency component of magnetoencephalographic data', IEEE Transactions on Biomedical Engineering, vol. 47, no. 5, pp. 642-653. https://doi.org/10.1109/10.841336
Sekihara, Kensuke ; Nagarajan, Srikantan S. ; Poeppel, David ; Miyauchi, Satoru ; Fujimaki, Norio ; Koizumi, Hideaki ; Miyashita, Yasushi. / Estimating neural sources from each time-frequency component of magnetoencephalographic data. In: IEEE Transactions on Biomedical Engineering. 2000 ; Vol. 47, No. 5. pp. 642-653.
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