Ephaptic conduction in a cardiac strand model with 3D electrodiffusion

Yoichiro Mori, Glenn I. Fishman, Charles Peskin

Research output: Contribution to journalArticle

Abstract

We study cardiac action potential propagation under severe reduction in gap junction conductance. We use a mathematical model of cellular electrical activity that takes into account both three-dimensional geometry and ionic concentration effects. Certain anatomical and biophysical parameters are varied to see their impact on cardiac action potential conduction velocity. This study uncovers quantitative features of ephaptic propagation that differ from previous studies based on one-dimensional models. We also identify a mode of cardiac action potential propagation in which the ephaptic and gap-junction-mediated mechanisms alternate. Our study demonstrates the usefulness of this modeling approach for electrophysiological systems especially when detailed membrane geometry plays an important role.

Original languageEnglish (US)
Pages (from-to)6463-6468
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number17
DOIs
StatePublished - Apr 29 2008

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Action Potentials
Gap Junctions
Theoretical Models
Membranes

Keywords

  • 3D model of electrophysiology
  • Ephaptic coupling
  • Gap junction

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Ephaptic conduction in a cardiac strand model with 3D electrodiffusion. / Mori, Yoichiro; Fishman, Glenn I.; Peskin, Charles.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, No. 17, 29.04.2008, p. 6463-6468.

Research output: Contribution to journalArticle

Mori, Yoichiro ; Fishman, Glenn I. ; Peskin, Charles. / Ephaptic conduction in a cardiac strand model with 3D electrodiffusion. In: Proceedings of the National Academy of Sciences of the United States of America. 2008 ; Vol. 105, No. 17. pp. 6463-6468.
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