Enzyme-triggered hydrogelation via self-assembly of alternating peptides

Xu Qin, Wenchun Xie, Sai Tian, Jiali Cai, Han Yuan, Zheng Yu, Glenn Butterfoss, Anne C. Khuong, Richard A. Gross

Research output: Contribution to journalArticle

Abstract

α-Chymotrypsin catalyzed oligomerization of the "dipeptide lego" KL-ethyl ester (OEt) in aqueous media triggers a rapid sol-gel transition due to formation of alternating (KL)x. Resulting mixed chain oligomers, at alkaline pH, self-assemble into β-sheets. Thereafter, intermolecular backbone hydrogen bonding between peptides causes formation of physically entangled nanofibrillar networks.

Original languageEnglish (US)
Pages (from-to)4839-4841
Number of pages3
JournalChemical Communications
Volume49
Issue number42
DOIs
StatePublished - May 25 2013

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Oligomerization
Dipeptides
Chymotrypsin
Oligomers
Self assembly
Peptides
Sol-gels
Esters
Hydrogen bonds
Enzymes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Qin, X., Xie, W., Tian, S., Cai, J., Yuan, H., Yu, Z., ... Gross, R. A. (2013). Enzyme-triggered hydrogelation via self-assembly of alternating peptides. Chemical Communications, 49(42), 4839-4841. https://doi.org/10.1039/c3cc41794h

Enzyme-triggered hydrogelation via self-assembly of alternating peptides. / Qin, Xu; Xie, Wenchun; Tian, Sai; Cai, Jiali; Yuan, Han; Yu, Zheng; Butterfoss, Glenn; Khuong, Anne C.; Gross, Richard A.

In: Chemical Communications, Vol. 49, No. 42, 25.05.2013, p. 4839-4841.

Research output: Contribution to journalArticle

Qin, X, Xie, W, Tian, S, Cai, J, Yuan, H, Yu, Z, Butterfoss, G, Khuong, AC & Gross, RA 2013, 'Enzyme-triggered hydrogelation via self-assembly of alternating peptides', Chemical Communications, vol. 49, no. 42, pp. 4839-4841. https://doi.org/10.1039/c3cc41794h
Qin, Xu ; Xie, Wenchun ; Tian, Sai ; Cai, Jiali ; Yuan, Han ; Yu, Zheng ; Butterfoss, Glenn ; Khuong, Anne C. ; Gross, Richard A. / Enzyme-triggered hydrogelation via self-assembly of alternating peptides. In: Chemical Communications. 2013 ; Vol. 49, No. 42. pp. 4839-4841.
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