Enhanced neuronal response induced by fast inhibition

Ramana Dodla, John Rinzel

Research output: Contribution to journalArticle

Abstract

We report a facilitatory role of inhibitory synaptic input that can enhance a neuron's firing rate, in contrast to the conventional belief that inhibition suppresses firing. We study this phenomenon using the Hodgkin-Huxley model of spike generation with random Poisson trains of subthreshold excitatory and inhibitory inputs. Enhancement occurs when, by chance, brief inhibition leads excitation with a favorable timing and counterintuitively induces a reduction of the spike threshold. The basic mechanism is also illustrated with the phaseplane analysis of a two variable model.

Original languageEnglish (US)
Article number010903
JournalPhysical Review E
Volume73
Issue number1
DOIs
StatePublished - Jan 2006

Fingerprint

Spike
spikes
Phase Plane Analysis
Neurons
neurons
Neuron
Timing
Siméon Denis Poisson
Enhancement
Excitation
time measurement
thresholds
augmentation
Model
excitation
Beliefs

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Condensed Matter Physics
  • Statistical and Nonlinear Physics
  • Mathematical Physics
  • Medicine(all)

Cite this

Enhanced neuronal response induced by fast inhibition. / Dodla, Ramana; Rinzel, John.

In: Physical Review E, Vol. 73, No. 1, 010903, 01.2006.

Research output: Contribution to journalArticle

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