Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations

Jorge Jaramillo, Jorge F. Mejias, Xiao-Jing Wang

Research output: Contribution to journalArticle

Abstract

Computational modeling of brain mechanisms of cognition has largely focused on the cortex, but recent experiments have shown that higher-order nuclei of the thalamus participate in major cognitive functions and are implicated in psychiatric disorders. Here, we show that a pulvino-cortical circuit model, composed of the pulvinar and two cortical areas, captures several physiological and behavioral observations related to the macaque pulvinar. Effective connections between the two cortical areas are gated by the pulvinar, allowing the pulvinar to shift the operation regime of these areas during attentional processing and working memory and resolve conflict in decision making. Furthermore, cortico-pulvinar projections that engage the thalamic reticular nucleus enable the pulvinar to estimate decision confidence. Finally, feedforward and feedback pulvino-cortical pathways participate in frequency-dependent inter-areal interactions that modify the relative hierarchical positions of cortical areas. Overall, our model suggests that the pulvinar provides crucial contextual modulation to cortical computations associated with cognition.

Original languageEnglish (US)
Pages (from-to)321-336.e9
JournalNeuron
Volume101
Issue number2
DOIs
StatePublished - Jan 16 2019

Fingerprint

Pulvinar
Cognition
Thalamic Nuclei
Macaca
Thalamus
Short-Term Memory
Psychiatry
Decision Making
Brain

Keywords

  • attention
  • attractor dynamics
  • confidence
  • cortex
  • decision making
  • hierarchy
  • oscillations
  • pulvinar
  • thalamic reticular nucleus
  • working memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations. / Jaramillo, Jorge; Mejias, Jorge F.; Wang, Xiao-Jing.

In: Neuron, Vol. 101, No. 2, 16.01.2019, p. 321-336.e9.

Research output: Contribution to journalArticle

Jaramillo, Jorge ; Mejias, Jorge F. ; Wang, Xiao-Jing. / Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations. In: Neuron. 2019 ; Vol. 101, No. 2. pp. 321-336.e9.
@article{53845282c8c54442873e472eba56fc4d,
title = "Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations",
abstract = "Computational modeling of brain mechanisms of cognition has largely focused on the cortex, but recent experiments have shown that higher-order nuclei of the thalamus participate in major cognitive functions and are implicated in psychiatric disorders. Here, we show that a pulvino-cortical circuit model, composed of the pulvinar and two cortical areas, captures several physiological and behavioral observations related to the macaque pulvinar. Effective connections between the two cortical areas are gated by the pulvinar, allowing the pulvinar to shift the operation regime of these areas during attentional processing and working memory and resolve conflict in decision making. Furthermore, cortico-pulvinar projections that engage the thalamic reticular nucleus enable the pulvinar to estimate decision confidence. Finally, feedforward and feedback pulvino-cortical pathways participate in frequency-dependent inter-areal interactions that modify the relative hierarchical positions of cortical areas. Overall, our model suggests that the pulvinar provides crucial contextual modulation to cortical computations associated with cognition.",
keywords = "attention, attractor dynamics, confidence, cortex, decision making, hierarchy, oscillations, pulvinar, thalamic reticular nucleus, working memory",
author = "Jorge Jaramillo and Mejias, {Jorge F.} and Xiao-Jing Wang",
year = "2019",
month = "1",
day = "16",
doi = "10.1016/j.neuron.2018.11.023",
language = "English (US)",
volume = "101",
pages = "321--336.e9",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "2",

}

TY - JOUR

T1 - Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations

AU - Jaramillo, Jorge

AU - Mejias, Jorge F.

AU - Wang, Xiao-Jing

PY - 2019/1/16

Y1 - 2019/1/16

N2 - Computational modeling of brain mechanisms of cognition has largely focused on the cortex, but recent experiments have shown that higher-order nuclei of the thalamus participate in major cognitive functions and are implicated in psychiatric disorders. Here, we show that a pulvino-cortical circuit model, composed of the pulvinar and two cortical areas, captures several physiological and behavioral observations related to the macaque pulvinar. Effective connections between the two cortical areas are gated by the pulvinar, allowing the pulvinar to shift the operation regime of these areas during attentional processing and working memory and resolve conflict in decision making. Furthermore, cortico-pulvinar projections that engage the thalamic reticular nucleus enable the pulvinar to estimate decision confidence. Finally, feedforward and feedback pulvino-cortical pathways participate in frequency-dependent inter-areal interactions that modify the relative hierarchical positions of cortical areas. Overall, our model suggests that the pulvinar provides crucial contextual modulation to cortical computations associated with cognition.

AB - Computational modeling of brain mechanisms of cognition has largely focused on the cortex, but recent experiments have shown that higher-order nuclei of the thalamus participate in major cognitive functions and are implicated in psychiatric disorders. Here, we show that a pulvino-cortical circuit model, composed of the pulvinar and two cortical areas, captures several physiological and behavioral observations related to the macaque pulvinar. Effective connections between the two cortical areas are gated by the pulvinar, allowing the pulvinar to shift the operation regime of these areas during attentional processing and working memory and resolve conflict in decision making. Furthermore, cortico-pulvinar projections that engage the thalamic reticular nucleus enable the pulvinar to estimate decision confidence. Finally, feedforward and feedback pulvino-cortical pathways participate in frequency-dependent inter-areal interactions that modify the relative hierarchical positions of cortical areas. Overall, our model suggests that the pulvinar provides crucial contextual modulation to cortical computations associated with cognition.

KW - attention

KW - attractor dynamics

KW - confidence

KW - cortex

KW - decision making

KW - hierarchy

KW - oscillations

KW - pulvinar

KW - thalamic reticular nucleus

KW - working memory

UR - http://www.scopus.com/inward/record.url?scp=85059670383&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85059670383&partnerID=8YFLogxK

U2 - 10.1016/j.neuron.2018.11.023

DO - 10.1016/j.neuron.2018.11.023

M3 - Article

VL - 101

SP - 321-336.e9

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 2

ER -