Endotoxin levels are associated with high-density lipoprotein, triglycerides, and troponin in patients with acute coronary syndrome and angina: Possible contributions from periodontal sources

David Goteiner, Ronald Craig, Robert Ashmen, Malvin N. Janal, Jj Barnet Eskin, Neal Lehrman

Research output: Contribution to journalArticle

Abstract

Background: Recent studies have reported an association between poor dental health and acute coronary syndrome (ACS). The purpose of this study was to correlate the presence of periodontitis with serum endotoxin/lipopolysaccharides (LPS), lipid profiles, troponin, and immunoglobulin G (IgG) antibody to Porphyromonas gingivalis in control patients or patients with ACS or angina at the time of hospital admission. Methods: Blood samples from 194 subjects presenting with ACS, angina, or non-cardiac chest pain were analyzed for endotoxin/LPS (Limulus amebocyte lysate assay), lipid profile, troponin, and IgG antibody to P. gingivalis. Data were collected from hospital charts and dental records, and health questionnaire responses. Results: Subjects with ACS or angina were more likely to have poor oral care, fewer remaining teeth, and increased alveolar radiographic bone loss compared to subjects with chest pain. In all subjects, endotoxin/LPS and IgG antibody to P. gingivalis tended to increase in association with increased radiographic bone loss. Endotoxin/LPS increased directly with triglyceride and troponin levels (P = 0.04 and P = 0.006, respectively) and inversely with high-density lipoprotein (HDL) levels (P = 0.002). IgG antibody to P. gingivalis levels was directly correlated with very low-density lipoprotein (P = 0.03) and triglycerides (P = 0.06) and inversely with low-density lipoprotein (P = 0.01). Conclusions: Results showedmore alveolar bone loss in patients with cardiac disease than in patients without cardiac disease, but therewas no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis. However, there were associations between endotoxin/LPS and levels of serum triglycerides, troponin, and HDL.

Original languageEnglish (US)
Pages (from-to)2331-2339
Number of pages9
JournalJournal of Periodontology
Volume79
Issue number12
DOIs
StatePublished - Dec 2008

Fingerprint

Troponin
HDL Lipoproteins
Acute Coronary Syndrome
Porphyromonas gingivalis
Endotoxins
Lipopolysaccharides
Immunoglobulin G
Antibodies
Alveolar Bone Loss
Triglycerides
Chest Pain
Heart Diseases
Tooth
Serum
Dental Records
Lipids
Horseshoe Crabs
VLDL Lipoproteins
Hospital Records
Periodontitis

Keywords

  • Acute coronary syndrome
  • Endotoxin
  • High-density lipoprotein
  • Periodontitis
  • Triglycerides
  • Troponin

ASJC Scopus subject areas

  • Periodontics

Cite this

Endotoxin levels are associated with high-density lipoprotein, triglycerides, and troponin in patients with acute coronary syndrome and angina : Possible contributions from periodontal sources. / Goteiner, David; Craig, Ronald; Ashmen, Robert; Janal, Malvin N.; Barnet Eskin, Jj; Lehrman, Neal.

In: Journal of Periodontology, Vol. 79, No. 12, 12.2008, p. 2331-2339.

Research output: Contribution to journalArticle

@article{7c2cdb7e3d3f41edb64952e0d67a2864,
title = "Endotoxin levels are associated with high-density lipoprotein, triglycerides, and troponin in patients with acute coronary syndrome and angina: Possible contributions from periodontal sources",
abstract = "Background: Recent studies have reported an association between poor dental health and acute coronary syndrome (ACS). The purpose of this study was to correlate the presence of periodontitis with serum endotoxin/lipopolysaccharides (LPS), lipid profiles, troponin, and immunoglobulin G (IgG) antibody to Porphyromonas gingivalis in control patients or patients with ACS or angina at the time of hospital admission. Methods: Blood samples from 194 subjects presenting with ACS, angina, or non-cardiac chest pain were analyzed for endotoxin/LPS (Limulus amebocyte lysate assay), lipid profile, troponin, and IgG antibody to P. gingivalis. Data were collected from hospital charts and dental records, and health questionnaire responses. Results: Subjects with ACS or angina were more likely to have poor oral care, fewer remaining teeth, and increased alveolar radiographic bone loss compared to subjects with chest pain. In all subjects, endotoxin/LPS and IgG antibody to P. gingivalis tended to increase in association with increased radiographic bone loss. Endotoxin/LPS increased directly with triglyceride and troponin levels (P = 0.04 and P = 0.006, respectively) and inversely with high-density lipoprotein (HDL) levels (P = 0.002). IgG antibody to P. gingivalis levels was directly correlated with very low-density lipoprotein (P = 0.03) and triglycerides (P = 0.06) and inversely with low-density lipoprotein (P = 0.01). Conclusions: Results showedmore alveolar bone loss in patients with cardiac disease than in patients without cardiac disease, but therewas no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis. However, there were associations between endotoxin/LPS and levels of serum triglycerides, troponin, and HDL.",
keywords = "Acute coronary syndrome, Endotoxin, High-density lipoprotein, Periodontitis, Triglycerides, Troponin",
author = "David Goteiner and Ronald Craig and Robert Ashmen and Janal, {Malvin N.} and {Barnet Eskin}, Jj and Neal Lehrman",
year = "2008",
month = "12",
doi = "10.1902/jop.2008.080068",
language = "English (US)",
volume = "79",
pages = "2331--2339",
journal = "Journal of Periodontology",
issn = "0022-3492",
publisher = "American Academy of Periodontology",
number = "12",

}

TY - JOUR

T1 - Endotoxin levels are associated with high-density lipoprotein, triglycerides, and troponin in patients with acute coronary syndrome and angina

T2 - Possible contributions from periodontal sources

AU - Goteiner, David

AU - Craig, Ronald

AU - Ashmen, Robert

AU - Janal, Malvin N.

AU - Barnet Eskin, Jj

AU - Lehrman, Neal

PY - 2008/12

Y1 - 2008/12

N2 - Background: Recent studies have reported an association between poor dental health and acute coronary syndrome (ACS). The purpose of this study was to correlate the presence of periodontitis with serum endotoxin/lipopolysaccharides (LPS), lipid profiles, troponin, and immunoglobulin G (IgG) antibody to Porphyromonas gingivalis in control patients or patients with ACS or angina at the time of hospital admission. Methods: Blood samples from 194 subjects presenting with ACS, angina, or non-cardiac chest pain were analyzed for endotoxin/LPS (Limulus amebocyte lysate assay), lipid profile, troponin, and IgG antibody to P. gingivalis. Data were collected from hospital charts and dental records, and health questionnaire responses. Results: Subjects with ACS or angina were more likely to have poor oral care, fewer remaining teeth, and increased alveolar radiographic bone loss compared to subjects with chest pain. In all subjects, endotoxin/LPS and IgG antibody to P. gingivalis tended to increase in association with increased radiographic bone loss. Endotoxin/LPS increased directly with triglyceride and troponin levels (P = 0.04 and P = 0.006, respectively) and inversely with high-density lipoprotein (HDL) levels (P = 0.002). IgG antibody to P. gingivalis levels was directly correlated with very low-density lipoprotein (P = 0.03) and triglycerides (P = 0.06) and inversely with low-density lipoprotein (P = 0.01). Conclusions: Results showedmore alveolar bone loss in patients with cardiac disease than in patients without cardiac disease, but therewas no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis. However, there were associations between endotoxin/LPS and levels of serum triglycerides, troponin, and HDL.

AB - Background: Recent studies have reported an association between poor dental health and acute coronary syndrome (ACS). The purpose of this study was to correlate the presence of periodontitis with serum endotoxin/lipopolysaccharides (LPS), lipid profiles, troponin, and immunoglobulin G (IgG) antibody to Porphyromonas gingivalis in control patients or patients with ACS or angina at the time of hospital admission. Methods: Blood samples from 194 subjects presenting with ACS, angina, or non-cardiac chest pain were analyzed for endotoxin/LPS (Limulus amebocyte lysate assay), lipid profile, troponin, and IgG antibody to P. gingivalis. Data were collected from hospital charts and dental records, and health questionnaire responses. Results: Subjects with ACS or angina were more likely to have poor oral care, fewer remaining teeth, and increased alveolar radiographic bone loss compared to subjects with chest pain. In all subjects, endotoxin/LPS and IgG antibody to P. gingivalis tended to increase in association with increased radiographic bone loss. Endotoxin/LPS increased directly with triglyceride and troponin levels (P = 0.04 and P = 0.006, respectively) and inversely with high-density lipoprotein (HDL) levels (P = 0.002). IgG antibody to P. gingivalis levels was directly correlated with very low-density lipoprotein (P = 0.03) and triglycerides (P = 0.06) and inversely with low-density lipoprotein (P = 0.01). Conclusions: Results showedmore alveolar bone loss in patients with cardiac disease than in patients without cardiac disease, but therewas no difference between the groups in the serum levels of endotoxin/LPS or IgG antibody to P. gingivalis. However, there were associations between endotoxin/LPS and levels of serum triglycerides, troponin, and HDL.

KW - Acute coronary syndrome

KW - Endotoxin

KW - High-density lipoprotein

KW - Periodontitis

KW - Triglycerides

KW - Troponin

UR - http://www.scopus.com/inward/record.url?scp=57349129307&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57349129307&partnerID=8YFLogxK

U2 - 10.1902/jop.2008.080068

DO - 10.1902/jop.2008.080068

M3 - Article

VL - 79

SP - 2331

EP - 2339

JO - Journal of Periodontology

JF - Journal of Periodontology

SN - 0022-3492

IS - 12

ER -