End-capped α-helices as modulators of protein function

Andrew B. Mahon, Paramjit S. Arora

Research output: Contribution to journalReview article

Abstract

Examination of complexes of proteins with other biomolecules reveals that proteins tend to interact with partners via folded subdomains, in which the backbone possesses secondary structure. a-Helices, the largest class of protein secondary structures, play fundamental roles in a multitude of highly specific protein-protein and protein-nucleic acids interactions. Herein, we describe the potential of a helix nucleation strategy to afford modulators of protein-protein interactions.

Original languageEnglish (US)
Pages (from-to)e57-e62
JournalDrug Discovery Today: Technologies
Volume9
Issue number1
DOIs
StatePublished - Jan 1 2012

    Fingerprint

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this