End-capped α-helices as modulators of protein function

Andrew B. Mahon, Paramjit Arora

Research output: Contribution to journalArticle

Abstract

Examination of complexes of proteins with other biomolecules reveals that proteins tend to interact with partners via folded subdomains, in which the backbone possesses secondary structure. a-Helices, the largest class of protein secondary structures, play fundamental roles in a multitude of highly specific protein-protein and protein-nucleic acids interactions. Herein, we describe the potential of a helix nucleation strategy to afford modulators of protein-protein interactions.

Original languageEnglish (US)
JournalDrug Discovery Today: Technologies
Volume9
Issue number1
DOIs
StatePublished - Mar 2012

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Proteins
Secondary Protein Structure
Nucleic Acids

ASJC Scopus subject areas

  • Drug Discovery
  • Biotechnology
  • Molecular Medicine

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End-capped α-helices as modulators of protein function. / Mahon, Andrew B.; Arora, Paramjit.

In: Drug Discovery Today: Technologies, Vol. 9, No. 1, 03.2012.

Research output: Contribution to journalArticle

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