Enamel: Molecular identity of its transepithelial ion transport system

Research output: Contribution to journalArticle

Abstract

Enamel is the most calcified tissue in vertebrates. It differs from bone in a number of characteristics including its origin from ectodermal epithelium, lack of remodeling capacity by the enamel forming cells, and absence of collagen. The enamel-forming cells known as ameloblasts, choreograph first the synthesis of a unique protein-rich matrix, followed by the mineralization of this matrix into a tissue that is ∼95% mineral. To do this, ameloblasts arrange the coordinated movement of ions across a cell barrier while removing matrix proteins and monitoring extracellular pH using a variety of buffering systems to enable the growth of carbonated apatite crystals. Although our knowledge of these processes and the molecular identity of the proteins involved in transepithelial ion transport has increased in the last decade, it remains limited compared to other cells. Here we present an overview of the evolution and development of enamel, its differences with bone, and describe the ion transport systems associated with ameloblasts.

Original languageEnglish (US)
JournalCell Calcium
DOIs
StateAccepted/In press - Feb 28 2017

Fingerprint

Ion Transport
Ameloblasts
Dental Enamel
Bone and Bones
Apatites
Extracellular Matrix Proteins
Minerals
Vertebrates
Proteins
Collagen
Epithelium
Ions
Growth

Keywords

  • CRAC channel
  • Enamel
  • Ion transport
  • PH

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

Enamel : Molecular identity of its transepithelial ion transport system. / Lacruz, Rodrigo.

In: Cell Calcium, 28.02.2017.

Research output: Contribution to journalArticle

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