Elevated Vascular Endothelial Growth Factor in Keloids: Relevance to Tissue Fibrosis

Anh D. Le, Qunzhou Zhang, Yidi Wu, Diana V. Messadi, Anita Akhondzadeh, Andrew L. Nguyen, Tara L. Aghaloo, A. Paul Kelly, Charles Bertolami

Research output: Contribution to journalArticle

Abstract

Excessive scar or keloid shares common features benign dermal growth. Yet, in contrast to malignant tumor, a keloid does not expand beyond the dermis. What triggers the continuing growth of a benign lesion? Deficient or overabundant levels of vascular endothelial growth factor have been reported to contribute to impaired or excessive wound healing. Although numerous studies have examined the pathophysiology of impaired wounds, little information has been provided on mechanisms of exuberant healing. The molecular basis of keloid formation is governed by the interplay of cellular signaling pathways, specific target gene activation, and the nature of the microenvironment. Recent works have demonstrated an accumulation of hypoxia-inducible factor-1α protein in freshly biopsied keloid tissues, thus providing first evidence that a local state of hypoxia exists in keloids. Our findings and the findings of others support at least two plausible mechanisms implicated in the development of fibrotic wounds, a state of ongoing fibroplasia or inflammation and an excessive accumulation of extracellular matrix. This article will review recent works examining the potential role of vascular endothelial growth factor in keloid pathogenesis with particular focus on its involvement in the two proposed pathological processes, a prolonged inflammation and an altered balance in extracellular matrix metabolism.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalCells Tissues Organs
Volume176
Issue number1-3
DOIs
StatePublished - 2004

Fingerprint

Keloid
Vascular Endothelial Growth Factor A
Fibrosis
Extracellular Matrix
Inflammation
Hypoxia-Inducible Factor 1
Wounds and Injuries
Pathologic Processes
Dermis
Growth
Wound Healing
Transcriptional Activation
Cicatrix
Skin
Neoplasms
Proteins

Keywords

  • Extracellular matrix
  • Fibrosis
  • Hypoxia-inducible factor-1α
  • Keloids
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Anatomy

Cite this

Le, A. D., Zhang, Q., Wu, Y., Messadi, D. V., Akhondzadeh, A., Nguyen, A. L., ... Bertolami, C. (2004). Elevated Vascular Endothelial Growth Factor in Keloids: Relevance to Tissue Fibrosis. Cells Tissues Organs, 176(1-3), 87-94. https://doi.org/10.1159/000075030

Elevated Vascular Endothelial Growth Factor in Keloids : Relevance to Tissue Fibrosis. / Le, Anh D.; Zhang, Qunzhou; Wu, Yidi; Messadi, Diana V.; Akhondzadeh, Anita; Nguyen, Andrew L.; Aghaloo, Tara L.; Kelly, A. Paul; Bertolami, Charles.

In: Cells Tissues Organs, Vol. 176, No. 1-3, 2004, p. 87-94.

Research output: Contribution to journalArticle

Le, AD, Zhang, Q, Wu, Y, Messadi, DV, Akhondzadeh, A, Nguyen, AL, Aghaloo, TL, Kelly, AP & Bertolami, C 2004, 'Elevated Vascular Endothelial Growth Factor in Keloids: Relevance to Tissue Fibrosis', Cells Tissues Organs, vol. 176, no. 1-3, pp. 87-94. https://doi.org/10.1159/000075030
Le, Anh D. ; Zhang, Qunzhou ; Wu, Yidi ; Messadi, Diana V. ; Akhondzadeh, Anita ; Nguyen, Andrew L. ; Aghaloo, Tara L. ; Kelly, A. Paul ; Bertolami, Charles. / Elevated Vascular Endothelial Growth Factor in Keloids : Relevance to Tissue Fibrosis. In: Cells Tissues Organs. 2004 ; Vol. 176, No. 1-3. pp. 87-94.
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