Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes

Rafael Song, Rohat Melik, Amr N. Rabie, Ahmed M.S. Ibrahim, David Moses, Ara Tan, Jongyoon Han, Samuel J. Lin

    Research output: Contribution to journalArticle

    Abstract

    Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations in situ along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes.

    Original languageEnglish (US)
    Pages (from-to)980-986
    Number of pages7
    JournalNature Materials
    Volume10
    Issue number12
    DOIs
    StatePublished - Jan 1 2011

    Fingerprint

    Ion selective membranes
    nerves
    ion concentration
    Chemical activation
    Modulation
    activation
    Ions
    membranes
    modulation
    stimulation
    ions
    spinal cord injuries
    epilepsy
    disabilities
    thresholds
    pain
    disorders
    propagation

    ASJC Scopus subject areas

    • Chemistry(all)
    • Materials Science(all)
    • Condensed Matter Physics
    • Mechanics of Materials
    • Mechanical Engineering

    Cite this

    Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes. / Song, Rafael; Melik, Rohat; Rabie, Amr N.; Ibrahim, Ahmed M.S.; Moses, David; Tan, Ara; Han, Jongyoon; Lin, Samuel J.

    In: Nature Materials, Vol. 10, No. 12, 01.01.2011, p. 980-986.

    Research output: Contribution to journalArticle

    Song, Rafael ; Melik, Rohat ; Rabie, Amr N. ; Ibrahim, Ahmed M.S. ; Moses, David ; Tan, Ara ; Han, Jongyoon ; Lin, Samuel J. / Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes. In: Nature Materials. 2011 ; Vol. 10, No. 12. pp. 980-986.
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