Effects of nicotine withdrawal on verbal working memory and associated brain response

Lawrence H. Sweet, Richard C. Mulligan, Colleen E. Finnerty, Beth A. Jerskey, Sean P. David, Ronald A. Cohen, Raymond Niaura

Research output: Contribution to journalArticle

Abstract

Previous literature has reported effects of nicotine withdrawal on brain function during cognitive tasks such as verbal working memory (VWM). Mechanisms of these withdrawal effects have not been clearly identified. Functional neuroimaging offers an objective method to examine brain mechanisms associated with observable behavior and subjective reports. To investigate these mechanisms, 12 smokers were administered a 2-Back VWM challenge during two functional magnetic resonance imaging sessions. Participants abstained from smoking prior to both sessions; however, they applied a nicotine patch before one session and a placebo patch prior to the other. Among regions that exhibited a significant response to the 2-Back during either session, withdrawal was associated with significantly greater deactivation in left and right temporal poles and left medial frontal gyrus. The magnitude of task-related activation showed a significant inverse relationship to craving in the majority of regions during placebo administration. Also, individual brain responses varied more during placebo, suggesting inefficient neural processing. Results suggest that differences in brain response to a VWM challenge during abstinence may be attributed to increased craving. Further deactivation of regions associated with the default network (medial frontal and anterior temporal clusters) during the placebo condition suggests further suspension of default activity, possibly to compensate for inefficient neural processing.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalPsychiatry Research - Neuroimaging
Volume183
Issue number1
DOIs
StatePublished - Jul 2010

Fingerprint

Nicotine
Short-Term Memory
Placebos
Brain
Tobacco Use Cessation Products
Functional Neuroimaging
Prefrontal Cortex
Cognition
Suspensions
Smoking
Magnetic Resonance Imaging
Craving

Keywords

  • Default network
  • Functional magnetic resonance imaging
  • N-Back paradigm

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

Effects of nicotine withdrawal on verbal working memory and associated brain response. / Sweet, Lawrence H.; Mulligan, Richard C.; Finnerty, Colleen E.; Jerskey, Beth A.; David, Sean P.; Cohen, Ronald A.; Niaura, Raymond.

In: Psychiatry Research - Neuroimaging, Vol. 183, No. 1, 07.2010, p. 69-74.

Research output: Contribution to journalArticle

Sweet, Lawrence H. ; Mulligan, Richard C. ; Finnerty, Colleen E. ; Jerskey, Beth A. ; David, Sean P. ; Cohen, Ronald A. ; Niaura, Raymond. / Effects of nicotine withdrawal on verbal working memory and associated brain response. In: Psychiatry Research - Neuroimaging. 2010 ; Vol. 183, No. 1. pp. 69-74.
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