Abstract
Although several studies have examined the effects of opioid antagonists on smoking behavior, there have been no reports of the potentially therapeutic combination of naltrexone and nicotine replacement therapy. The primary objective of the present study was to determine whether naltrexone reduced reactivity to smoking cues among abstinent smokers treated with nicotine replacement. Twenty participants were instructed to abstain from smoking cigarettes for 9 h while using nicotine replacement therapy. Participants were subsequently treated with either naltrexone (50 mg) or placebo before being exposed to smoking cues. Results indicated that the smokers who received the placebo responded to smoking cue exposure with increases in urge to smoke and increases in negative affect. Participants who received naltrexone did not show any increase in urge or negative affect and showed a decrease in withdrawal symptoms after exposure to smoking cues. Although preliminary, the findings suggest that naltrexone may work in combination with nicotine replacement therapies to block the effects of smoking stimuli in abstinent smokers.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 139-143 |
| Number of pages | 5 |
| Journal | Psychopharmacology |
| Volume | 142 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1999 |
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Keywords
- Craving
- Naltrexone
- Nicotine replacement patch Smoking cue
- Urge
ASJC Scopus subject areas
- Pharmacology
Cite this
Effects of naltrexone with nicotine replacement on smoking cue reactivity : Preliminary results. / Hutchison, Kent E.; Monti, Peter M.; Rohsenow, Damaris J.; Swift, Robert M.; Colby, Suzanne M.; Gnys, Maryann; Niaura, Raymond; Sirota, Alan D.
In: Psychopharmacology, Vol. 142, No. 2, 1999, p. 139-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of naltrexone with nicotine replacement on smoking cue reactivity
T2 - Preliminary results
AU - Hutchison, Kent E.
AU - Monti, Peter M.
AU - Rohsenow, Damaris J.
AU - Swift, Robert M.
AU - Colby, Suzanne M.
AU - Gnys, Maryann
AU - Niaura, Raymond
AU - Sirota, Alan D.
PY - 1999
Y1 - 1999
N2 - Although several studies have examined the effects of opioid antagonists on smoking behavior, there have been no reports of the potentially therapeutic combination of naltrexone and nicotine replacement therapy. The primary objective of the present study was to determine whether naltrexone reduced reactivity to smoking cues among abstinent smokers treated with nicotine replacement. Twenty participants were instructed to abstain from smoking cigarettes for 9 h while using nicotine replacement therapy. Participants were subsequently treated with either naltrexone (50 mg) or placebo before being exposed to smoking cues. Results indicated that the smokers who received the placebo responded to smoking cue exposure with increases in urge to smoke and increases in negative affect. Participants who received naltrexone did not show any increase in urge or negative affect and showed a decrease in withdrawal symptoms after exposure to smoking cues. Although preliminary, the findings suggest that naltrexone may work in combination with nicotine replacement therapies to block the effects of smoking stimuli in abstinent smokers.
AB - Although several studies have examined the effects of opioid antagonists on smoking behavior, there have been no reports of the potentially therapeutic combination of naltrexone and nicotine replacement therapy. The primary objective of the present study was to determine whether naltrexone reduced reactivity to smoking cues among abstinent smokers treated with nicotine replacement. Twenty participants were instructed to abstain from smoking cigarettes for 9 h while using nicotine replacement therapy. Participants were subsequently treated with either naltrexone (50 mg) or placebo before being exposed to smoking cues. Results indicated that the smokers who received the placebo responded to smoking cue exposure with increases in urge to smoke and increases in negative affect. Participants who received naltrexone did not show any increase in urge or negative affect and showed a decrease in withdrawal symptoms after exposure to smoking cues. Although preliminary, the findings suggest that naltrexone may work in combination with nicotine replacement therapies to block the effects of smoking stimuli in abstinent smokers.
KW - Craving
KW - Naltrexone
KW - Nicotine replacement patch Smoking cue
KW - Urge
UR - http://www.scopus.com/inward/record.url?scp=0032932672&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032932672&partnerID=8YFLogxK
U2 - 10.1007/s002130050872
DO - 10.1007/s002130050872
M3 - Article
C2 - 10102765
AN - SCOPUS:0032932672
VL - 142
SP - 139
EP - 143
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 2
ER -