Effects of microinjections of 5,7-dihydroxytryptamine in the suprachiasmatic nuclei of the rat on serotonin reuptake and the circadian variation of corticosterone levels

J. H. Williams, V. M. Miall Allen, M. Klinowski, Efrain Azmitia

Research output: Contribution to journalArticle

Abstract

The role of the 5-hydroxytryptamine (5-HT) terminals in the suprachiasmatic nucleus (SCN) in the production of the circadian variation of corticosterone secretion was investigated by lesioning the 5-HT inputs to the SCN with 5,7-dihydroxytryptamine (5,7-DHT). Vehicle-injected animals showed a normal circadian variation of corticosterone levels. In contrast, the mean corticosterone levels of the 5,7-DHT-lesioned group were intermediate between control peak and trough values, and although the individual rats showed fluctuations, no significant circadian variation was present in the group as a whole. 3H-5-HT reuptake in the SCN was reduced to 38% of the mean control level in the 5,7-DHT-lesioned group, but ventromedial hypothalamic 3H-5-HT reuptake was only decreased to 82% of control. These results indicated that the SCN 5-HT terminals may play an important role in the synchronization of the circadian variation of corticosterone secretion.

Original languageEnglish (US)
Pages (from-to)431-435
Number of pages5
JournalNeuroendocrinology
Volume36
Issue number6
StatePublished - 1983

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5,7-Dihydroxytryptamine
Suprachiasmatic Nucleus
Microinjections
Corticosterone
Serotonin

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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Effects of microinjections of 5,7-dihydroxytryptamine in the suprachiasmatic nuclei of the rat on serotonin reuptake and the circadian variation of corticosterone levels. / Williams, J. H.; Miall Allen, V. M.; Klinowski, M.; Azmitia, Efrain.

In: Neuroendocrinology, Vol. 36, No. 6, 1983, p. 431-435.

Research output: Contribution to journalArticle

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abstract = "The role of the 5-hydroxytryptamine (5-HT) terminals in the suprachiasmatic nucleus (SCN) in the production of the circadian variation of corticosterone secretion was investigated by lesioning the 5-HT inputs to the SCN with 5,7-dihydroxytryptamine (5,7-DHT). Vehicle-injected animals showed a normal circadian variation of corticosterone levels. In contrast, the mean corticosterone levels of the 5,7-DHT-lesioned group were intermediate between control peak and trough values, and although the individual rats showed fluctuations, no significant circadian variation was present in the group as a whole. 3H-5-HT reuptake in the SCN was reduced to 38{\%} of the mean control level in the 5,7-DHT-lesioned group, but ventromedial hypothalamic 3H-5-HT reuptake was only decreased to 82{\%} of control. These results indicated that the SCN 5-HT terminals may play an important role in the synchronization of the circadian variation of corticosterone secretion.",
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AB - The role of the 5-hydroxytryptamine (5-HT) terminals in the suprachiasmatic nucleus (SCN) in the production of the circadian variation of corticosterone secretion was investigated by lesioning the 5-HT inputs to the SCN with 5,7-dihydroxytryptamine (5,7-DHT). Vehicle-injected animals showed a normal circadian variation of corticosterone levels. In contrast, the mean corticosterone levels of the 5,7-DHT-lesioned group were intermediate between control peak and trough values, and although the individual rats showed fluctuations, no significant circadian variation was present in the group as a whole. 3H-5-HT reuptake in the SCN was reduced to 38% of the mean control level in the 5,7-DHT-lesioned group, but ventromedial hypothalamic 3H-5-HT reuptake was only decreased to 82% of control. These results indicated that the SCN 5-HT terminals may play an important role in the synchronization of the circadian variation of corticosterone secretion.

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