Effects of methadone on QT-interval dispersion

Mori J. Krantz, Christopher M. Lowery, Bridget A. Martell, Marc Gourevitch, Julia H. Arnsten

Research output: Contribution to journalArticle

Abstract

Study Objective. To evaluate the effects of methadone on QT-interval dispersion. Design. Single-center, prospective, cohort study. Setting. Methadone maintenance treatment facility. Patients. One hundred eighteen patients who were newly admitted to the facility. Intervention. Twelve-lead electrocardiograms (ECGs) were performed in patients at both baseline and 6 months after the start of methadone therapy. Measurements and Main Results. The ECGs were manually interpreted, and investigators were blinded to time interval and methadone dose. At least eight discernible ECG leads were required for study inclusion. Mean differences between baseline and follow-up rate-corrected QT (QTc) interval and QT dispersion were compared. Multivariate associations between clinical characteristics and magnitude of change in QT dispersion were assessed using linear regression. Mean ± SD baseline QT dispersion was 32.9 ± 12 msec, which increased to 42.4 ± 15 msec (+9.5 ± 18.6 msec, p<0.0001) after 6 months of therapy. The QTc increased by a similar magnitude (+14.1 msec, p<0.0001). No QT dispersion value exceeded 100 msec. The only variable associated with a greater increase in QT dispersion was antidepressant therapy (20 vs 8.5 msec, p=0.04). Conclusion. Methadone modestly increased both QTc interval and QT dispersion. Increased QT dispersion reflects heterogeneous cardiac repolarization and occurs with nonantiarrhythmic agents, such as synthetic opioids. However, the magnitude of this effect appears to be substantially less with methadone than with antiarrhythmic drugs.

Original languageEnglish (US)
Pages (from-to)1523-1529
Number of pages7
JournalPharmacotherapy
Volume25
Issue number11 I
DOIs
StatePublished - Nov 2005

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Methadone
Electrocardiography
Anti-Arrhythmia Agents
Therapeutics
Opioid Analgesics
Antidepressive Agents
Linear Models
Cohort Studies
Research Personnel
Prospective Studies

Keywords

  • Methadone
  • QT dispersion
  • QT prolongation

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Krantz, M. J., Lowery, C. M., Martell, B. A., Gourevitch, M., & Arnsten, J. H. (2005). Effects of methadone on QT-interval dispersion. Pharmacotherapy, 25(11 I), 1523-1529. https://doi.org/10.1592/phco.2005.25.11.1523

Effects of methadone on QT-interval dispersion. / Krantz, Mori J.; Lowery, Christopher M.; Martell, Bridget A.; Gourevitch, Marc; Arnsten, Julia H.

In: Pharmacotherapy, Vol. 25, No. 11 I, 11.2005, p. 1523-1529.

Research output: Contribution to journalArticle

Krantz, MJ, Lowery, CM, Martell, BA, Gourevitch, M & Arnsten, JH 2005, 'Effects of methadone on QT-interval dispersion', Pharmacotherapy, vol. 25, no. 11 I, pp. 1523-1529. https://doi.org/10.1592/phco.2005.25.11.1523
Krantz, Mori J. ; Lowery, Christopher M. ; Martell, Bridget A. ; Gourevitch, Marc ; Arnsten, Julia H. / Effects of methadone on QT-interval dispersion. In: Pharmacotherapy. 2005 ; Vol. 25, No. 11 I. pp. 1523-1529.
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