Effects of increasing osmolality on rat ileal smooth muscle

Joel Schiff, Norbert I A Overweg

Research output: Contribution to journalArticle

Abstract

The effects of changing bathing medium osmolality on tension generation in smooth muscle were studied on potassium-depolarized segments of rat ileum. Increasing the tonicity of the medium evokes a transient relaxation of the smooth muscle; restoration of isotonicity evokes a transient contraction of similar amplitude and time course. While immersed in hypertonic media of less than 1.3 times normal tonicity, the smooth muscle slowly increases its isometric tension; in media of nearly twice normal tonicity, the smooth muscle loses tension. All of these effects occur whether the medium is made hypertonic with added NaCl or sucrose.

Original languageEnglish (US)
Pages (from-to)75-79
Number of pages5
JournalPflugers Archiv European Journal of Physiology
Volume389
Issue number1
DOIs
StatePublished - Dec 1980

Fingerprint

Osmolar Concentration
Smooth Muscle
Muscle
Rats
Muscle Tonus
Ileum
Restoration
Sucrose
Potassium

Keywords

  • Hypertonicity
  • Ileum
  • Osmolality
  • Smooth muscle

ASJC Scopus subject areas

  • Physiology

Cite this

Effects of increasing osmolality on rat ileal smooth muscle. / Schiff, Joel; Overweg, Norbert I A.

In: Pflugers Archiv European Journal of Physiology, Vol. 389, No. 1, 12.1980, p. 75-79.

Research output: Contribution to journalArticle

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