Effects of acute sleep deprivation on motor and reversal learning in mice

Andrew W. Varga, Mihwa Kang, Priyanka V. Ramesh, Eric Klann

Research output: Contribution to journalArticle

Abstract

Sleep supports the formation of a variety of declarative and non-declarative memories, and sleep deprivation often impairs these types of memories. In human subjects, natural sleep either during a nap or overnight leads to long-lasting improvements in visuomotor and fine motor tasks, but rodent models recapitulating these findings have been scarce. Here we present evidence that 5. h of acute sleep deprivation impairs mouse skilled reach learning compared to a matched period of ad libitum sleep. In sleeping mice, the duration of total sleep time during the 5. h of sleep opportunity or during the first bout of sleep did not correlate with ultimate gain in motor performance. In addition, we observed that reversal learning during the skilled reaching task was also affected by sleep deprivation. Consistent with this observation, 5. h of sleep deprivation also impaired reversal learning in the water-based Y-maze. In conclusion, acute sleep deprivation negatively impacts subsequent motor and reversal learning and memory.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalNeurobiology of Learning and Memory
Volume114
DOIs
StatePublished - Oct 2014

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Keywords

  • Motor learning
  • Reversal learning
  • Skilled reach learning
  • Sleep deprivation
  • Y-maze

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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