Effects of acute nicotine abstinence on cue-elicited ventral striatum/nucleus accumbens activation in female cigarette smokers: A functional magnetic resonance imaging study

Sean P. David, Marcus R. Munafò, Heidi Johansen-Berg, James MacKillop, Lawrence H. Sweet, Ronald A. Cohen, Raymond Niaura, Robert D. Rogers, Paul M. Matthews, Robert T. Walton

Research output: Contribution to journalArticle

Abstract

To achieve greater understanding of the brain mechanisms underlying nicotine craving in female smokers, we examined the influence of nicotine non-abstinence vs. acute nicotine abstinence on cue-elicited activation of the ventral striatum. Eight female smokers underwent an event-related functional magnetic resonance imaging (fMRI) paradigm presenting randomized sequences of smoking-related and non-smoking related pictures. Participants were asked to indicate by a key press the gender of individuals in smoking-related and non-smoking related pictures (gender discrimination task), to maintain and evaluate attention to the pictures. There was a significant effect of smoking condition on reaction times (RT) for a gender discrimination task intended to assess and maintain attention to the photographs-suggesting a deprivation effect of acute nicotine abstinence and a statistical trend indicating greater RTs for smoking cues than neutral cues. BOLD contrast (smoking vs. non-smoking cues) was greater in the non-abstinent vs. acutely abstinent conditions in the ventral striatum including the nucleus accumbens (VS/NAc). Moreover, a significant positive correlation was observed between baseline cigarette craving prior to scanning and VS/NAc activation (r = 0.84, p = 0.009), but only in the non-abstinent condition. These results may either be explained by ceiling effects of nicotine withdrawal in the abstinent condition or, may indicate reduced relative activation (smoking vs. neutral contrast) in the VS/NAc in the abstinent vs. non-abstinent conditions in this group of female smokers.

Original languageEnglish (US)
Pages (from-to)43-57
Number of pages15
JournalBrain Imaging and Behavior
Volume1
Issue number3-4
DOIs
StatePublished - Nov 2007

Fingerprint

Nucleus Accumbens
Nicotine
Tobacco Products
Cues
Smoking
Magnetic Resonance Imaging
Reaction Time
Ventral Striatum
Brain

Keywords

  • Cue reactivity
  • fMRI
  • Nucleus accumbens
  • Smoking
  • Tobacco
  • Ventral striatum

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Radiology Nuclear Medicine and imaging

Cite this

Effects of acute nicotine abstinence on cue-elicited ventral striatum/nucleus accumbens activation in female cigarette smokers : A functional magnetic resonance imaging study. / David, Sean P.; Munafò, Marcus R.; Johansen-Berg, Heidi; MacKillop, James; Sweet, Lawrence H.; Cohen, Ronald A.; Niaura, Raymond; Rogers, Robert D.; Matthews, Paul M.; Walton, Robert T.

In: Brain Imaging and Behavior, Vol. 1, No. 3-4, 11.2007, p. 43-57.

Research output: Contribution to journalArticle

David, Sean P. ; Munafò, Marcus R. ; Johansen-Berg, Heidi ; MacKillop, James ; Sweet, Lawrence H. ; Cohen, Ronald A. ; Niaura, Raymond ; Rogers, Robert D. ; Matthews, Paul M. ; Walton, Robert T. / Effects of acute nicotine abstinence on cue-elicited ventral striatum/nucleus accumbens activation in female cigarette smokers : A functional magnetic resonance imaging study. In: Brain Imaging and Behavior. 2007 ; Vol. 1, No. 3-4. pp. 43-57.
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