Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse

Joseph Guttenplan, Michael Chen, Wieslawa Kosinska, Seth Thompson, Zhonglin Zhao, Leonard A. Cohen

Research output: Contribution to journalArticle

Abstract

Consumption of lycopene has been associated with reduced risk of prostate cancer. We have investigated the effects of lycopene, fed as a lycopene-rich tomato oleoresin (LTO) at two doses, on in vivo mutagenesis in prostate, colon, and lungs of lacZ mice. Both short-term benzo[a]pyrene (BaP)- induced and long-term spontaneous mutagenesis were monitored. Non-significant inhibition of spontaneous mutagenesis in prostate and colon was observed at the higher dose of LTO, and the observation of inhibition in colon was facilitated by an unusually high spontaneous mutagenesis rate. BaP-induced mutagenesis was slightly inhibited by LTO in prostate. However, enhancement of BaP-induced-mutagenesis was observed in colon and lung. These results indicate that any antimutagenic effects of LTO may be organospecific.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalCancer Letters
Volume164
Issue number1
DOIs
StatePublished - Mar 10 2001

Fingerprint

Benzo(a)pyrene
Mutagenesis
Prostate
Colon
Lycopersicon esculentum
Diet
Lung
Antimutagenic Agents
lycopene
Prostatic Neoplasms
Observation
oleoresins

Keywords

  • lacZ
  • Lycopene
  • Muta™ Mouse
  • Mutagenesis
  • Prostate

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse. / Guttenplan, Joseph; Chen, Michael; Kosinska, Wieslawa; Thompson, Seth; Zhao, Zhonglin; Cohen, Leonard A.

In: Cancer Letters, Vol. 164, No. 1, 10.03.2001, p. 1-6.

Research output: Contribution to journalArticle

Guttenplan, Joseph ; Chen, Michael ; Kosinska, Wieslawa ; Thompson, Seth ; Zhao, Zhonglin ; Cohen, Leonard A. / Effects of a lycopene-rich diet on spontaneous and benzo[a]pyrene-induced mutagenesis in prostate, colon and lungs of the lacZ mouse. In: Cancer Letters. 2001 ; Vol. 164, No. 1. pp. 1-6.
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