Effect of Topically-applied Solutions of Iodine, Sodium Fluoride, or Chlorhexidine on Oral Bacteria and Caries in Rats

Page W. Caufield, Juan M. Navia, Angela M. Rogers, Celestino Alvarez

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Antibacterial levels of iodine, chlorhexidine, or sodium fluoride were topically applied to the molar teeth of rats. The effect of these agents on buccal and sulcal caries, as well as on certain oral bacterial populations was assayed. All three agents exerted a significant cariostatic effect which was site specific. Buccal caries incidence and reductions appeared correlated to S. mutans counts, while sulcal caries was better correlated to total cultivable counts. These studies suggested that the simultaneous application of iodine and NaF might exert an additive cariostatic effect.

Original languageEnglish (US)
Pages (from-to)927-932
Number of pages6
JournalJournal of dental research
Issue number5
StatePublished - May 1981


ASJC Scopus subject areas

  • Dentistry(all)

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