Effect of respiratory syncytial virus infection on mice with protein malnutrition

V. Pena-Cruz, Carol Reiss, K. McIntosh

Research output: Contribution to journalArticle

Abstract

Respiratory syncytial virus (RSV) pulmonary infection was produced in BALB/c mice fed protein-deficient diets in an effort to understand the severity of viral pneumonia in infants in the developing countries. As in previously published experiments with Sendai virus, animals on the deficient diet became clinically malnourished, and certain aspects of their cell-mediated immunity were altered. The course of RSV infection in protein-deprived mice was essentially identical to that in normally nourished animals. The titer of virus recovered from lung homogenates over time, as well as the histological picture of bronchiolitis, were identical under all experimental conditions. This model, unlike that of Sendai virus infection, fails to demonstrate an effect of protein malnutrition on RSV infection.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalJournal of Medical Virology
Volume33
Issue number4
StatePublished - 1991

Fingerprint

Respiratory Syncytial Virus Infections
Malnutrition
Sendai virus
Viral Pneumonia
Diet
Lung
Bronchiolitis
Proteins
Virus Diseases
Viral Load
Cellular Immunity
Developing Countries

Keywords

  • Nutrition
  • Pulmonary infection
  • RSV

ASJC Scopus subject areas

  • Virology

Cite this

Effect of respiratory syncytial virus infection on mice with protein malnutrition. / Pena-Cruz, V.; Reiss, Carol; McIntosh, K.

In: Journal of Medical Virology, Vol. 33, No. 4, 1991, p. 219-223.

Research output: Contribution to journalArticle

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