Effect of prior hepatitis B infection on serum IgE levels in patients with human immunodeficiency virus infection

Ma Lourdes B De Asis, David L. Rosenstreich, Chee Jen Chang, Marc Gourevitch, Catherine Butkus Small

Research output: Contribution to journalArticle

Abstract

Background: Advanced HIV infection is associated with increased serum IgE levels, which in turn have been associated with a poor prognosis. Our preliminary data revealed that serum IgE levels were significantly elevated in HIV seropositive injection drug users compared with HIV seropositive non- injection drug users. Since vital hepatitis is common among injection drug users and is itself associated with elevated serum IgE levels, we studied whether there was an association between increased serum IgE levels and positive hepatitis serology in HIV-seropositive patients. Methods: A retrospective cross-sectional analysis was performed. The medical records of ambulatory HIV-infected patients in an ongoing study were reviewed. Forty- five patients had hepatitis A, B, and C serology performed. The associations between serum IgE levels and hepatitis A, B and C antibodies, CD4 and CD8 lymphocyte percentages, injection drug use, and sex were analyzed by univariate and multiple regression analyses. Results: On univariate analyses, hepatitis B antibody was significantly associated with increased serum IgE levels in HIV-infected subjects (P = .013), especially in those with AIDS (P = .015). Multiple regression analyses controlling for CD4 lymphocyte percentages, sex, and drug use, confirmed that hepatitis B antibody status remained significantly associated with increased serum IgE levels (P = .05). There was no association of serum IgE levels with hepatitis A or C serology. Conclusion: Prior hepatitis B infection is significantly associated with increased serum IgE levels in advanced HIV infection. The clinical implications of this finding deserve further study.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalAnnals of Allergy, Asthma and Immunology
Volume80
Issue number1
StatePublished - 1998

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Virus Diseases
Hepatitis B
Immunoglobulin E
HIV
Infection
Serum
Hepatitis B Antibodies
Serology
Drug Users
Injections
Hepatitis A
Hepatitis C
Hepatitis
HIV Infections
Regression Analysis
Lymphocytes
Hepatitis A Antibodies
Hepatitis C Antibodies
Pharmaceutical Preparations
Medical Records

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Effect of prior hepatitis B infection on serum IgE levels in patients with human immunodeficiency virus infection. / De Asis, Ma Lourdes B; Rosenstreich, David L.; Chang, Chee Jen; Gourevitch, Marc; Small, Catherine Butkus.

In: Annals of Allergy, Asthma and Immunology, Vol. 80, No. 1, 1998, p. 35-38.

Research output: Contribution to journalArticle

De Asis, Ma Lourdes B ; Rosenstreich, David L. ; Chang, Chee Jen ; Gourevitch, Marc ; Small, Catherine Butkus. / Effect of prior hepatitis B infection on serum IgE levels in patients with human immunodeficiency virus infection. In: Annals of Allergy, Asthma and Immunology. 1998 ; Vol. 80, No. 1. pp. 35-38.
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