Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: Implications for host adaptation mechanisms

Dominik Wodarz, David N. Levy

Research output: Contribution to journalReview article

Abstract

The dynamics between human immunodeficiency virus type 1 and the immune system have been studied both experimentally and mathematically, exploring aspects of host adaptation and viral mechanisms to escape host control. The majority of this work, however, has been performed assuming that any cell can only be infected by one copy of the virus. In recent years, it has become clear that multiple copies of the virus can infect the same cell, a process we refer to as co-infection. Here, we review this topic and discuss how immune control of the infection and the ability of the virus to escape immune control is affected by co-infection.

Original languageEnglish (US)
Pages (from-to)926-937
Number of pages12
JournalExperimental Biology and Medicine
Volume236
Issue number8
DOIs
StatePublished - Aug 1 2011

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Keywords

  • Co-infection
  • Cytotoxic t lymphocytes
  • Escape
  • Immune control
  • Mathematical model
  • Multiple infection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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