Effect of hospitalwide change in clindamycin dosing schedule on clinical outcome.

D. Buchwald, S. B. Soumerai, Nancy Van Devanter, M. R. Wessels, J. Avorn

Research output: Contribution to journalArticle

Abstract

We compared clinical outcomes of 65 hospitalized patients receiving clindamycin before and 59 after a sudden hospitalwide shift in dosing schedules for this drug from 600 mg every 6 hours to 600 mg every 8 hours. Outcomes studied included the efficacy of antibiotic treatment, length of febrile period, and frequency of adverse effects. We also compared and controlled for patient characteristics such as age, sex, presence of multiple diagnoses, length of therapy, and concurrent use of other antibiotics. There were no differences in measured clinical outcomes between the two groups. Treatment was successful in 87% of both groups. The average number of febrile days was 5.1 in the first group and 3.9 in the second (P less than .05). Patients on 6-hourly therapy experienced a 12% rate of antibiotic-related adverse effects vs. 5% for the 8-hourly group (P greater than .05). These data support the clinical rationale and safety of a hospitalwide reduction in the frequency of clindamycin dosing. In addition to considerable pharmacy and nursing time saved, this change also saved greater than $40,000 annually in antibiotic costs.

Original languageEnglish (US)
Pages (from-to)619-624
Number of pages6
JournalReviews of Infectious Diseases
Volume11
Issue number4
StatePublished - Jul 1989

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Clindamycin
Appointments and Schedules
Anti-Bacterial Agents
Fever
Nursing
Therapeutics
Safety
Costs and Cost Analysis
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Buchwald, D., Soumerai, S. B., Van Devanter, N., Wessels, M. R., & Avorn, J. (1989). Effect of hospitalwide change in clindamycin dosing schedule on clinical outcome. Reviews of Infectious Diseases, 11(4), 619-624.

Effect of hospitalwide change in clindamycin dosing schedule on clinical outcome. / Buchwald, D.; Soumerai, S. B.; Van Devanter, Nancy; Wessels, M. R.; Avorn, J.

In: Reviews of Infectious Diseases, Vol. 11, No. 4, 07.1989, p. 619-624.

Research output: Contribution to journalArticle

Buchwald, D, Soumerai, SB, Van Devanter, N, Wessels, MR & Avorn, J 1989, 'Effect of hospitalwide change in clindamycin dosing schedule on clinical outcome.', Reviews of Infectious Diseases, vol. 11, no. 4, pp. 619-624.
Buchwald, D. ; Soumerai, S. B. ; Van Devanter, Nancy ; Wessels, M. R. ; Avorn, J. / Effect of hospitalwide change in clindamycin dosing schedule on clinical outcome. In: Reviews of Infectious Diseases. 1989 ; Vol. 11, No. 4. pp. 619-624.
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