Effect of folate on phenytoin hyperplasia.

H. J. Drew, Richard Vogel, W. Molofsky, H. Baker, O. Frank

Research output: Contribution to journalArticle

Abstract

There have been some reports that folic acid inhibits phenytoin-induced gingival hyperplasia. The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.

Original languageEnglish (US)
Pages (from-to)350-356
Number of pages7
JournalJournal of Clinical Periodontology
Volume14
Issue number6
StatePublished - Jul 1987

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Phenytoin
Folic Acid
Hyperplasia
Gingival Hyperplasia
Gingival Overgrowth
Placebos
Topical Administration
Double-Blind Method
Control Groups

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Drew, H. J., Vogel, R., Molofsky, W., Baker, H., & Frank, O. (1987). Effect of folate on phenytoin hyperplasia. Journal of Clinical Periodontology, 14(6), 350-356.

Effect of folate on phenytoin hyperplasia. / Drew, H. J.; Vogel, Richard; Molofsky, W.; Baker, H.; Frank, O.

In: Journal of Clinical Periodontology, Vol. 14, No. 6, 07.1987, p. 350-356.

Research output: Contribution to journalArticle

Drew, HJ, Vogel, R, Molofsky, W, Baker, H & Frank, O 1987, 'Effect of folate on phenytoin hyperplasia.', Journal of Clinical Periodontology, vol. 14, no. 6, pp. 350-356.
Drew HJ, Vogel R, Molofsky W, Baker H, Frank O. Effect of folate on phenytoin hyperplasia. Journal of Clinical Periodontology. 1987 Jul;14(6):350-356.
Drew, H. J. ; Vogel, Richard ; Molofsky, W. ; Baker, H. ; Frank, O. / Effect of folate on phenytoin hyperplasia. In: Journal of Clinical Periodontology. 1987 ; Vol. 14, No. 6. pp. 350-356.
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