Effect of bundle branch block on cardiac output

A whole heart simulation study

Edward J. Vigmond, Clyde Clements, David M. McQueen, Charles Peskin

Research output: Contribution to journalArticle

Abstract

The heart is an electrically controlled fluid pump which operates by mechanical contraction. Whole heart modelling is a computationally daunting task which must incorporate several subsystems: mechanical, electrical, and fluidic. Numerous feedback mechanisms on many levels, and operating at different scales, exist to finely control behaviour. Understanding these interactions is necessary to understand heart operation, as well as pathologies and therapies. A review of the components in such a model is given. The authors then present a framework for their electro-mechano-fluidic whole heart model based on cable methods. The model incorporates atria and ventricles, and has functioning valves with papillary muscles. The effect of altered propagation due to left and right bundle branch block on cardiac output is examined using the cable-based model. Results are compared to clinically observed phenomena. Good agreement was obtained, but tighter coupling of mechanical and electrical events is needed to fully account for behaviour. Cable-based models offer an alternative to continuum models.

Original languageEnglish (US)
Pages (from-to)520-542
Number of pages23
JournalProgress in Biophysics and Molecular Biology
Volume97
Issue number2-3
DOIs
StatePublished - Jun 2008

Fingerprint

Bundle-Branch Block
Cardiac Output
Behavior Control
Papillary Muscles
Pathology
Therapeutics

Keywords

  • Bundle branch block
  • Immersed boundary method
  • Navier-Stokes

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics

Cite this

Effect of bundle branch block on cardiac output : A whole heart simulation study. / Vigmond, Edward J.; Clements, Clyde; McQueen, David M.; Peskin, Charles.

In: Progress in Biophysics and Molecular Biology, Vol. 97, No. 2-3, 06.2008, p. 520-542.

Research output: Contribution to journalArticle

Vigmond, Edward J. ; Clements, Clyde ; McQueen, David M. ; Peskin, Charles. / Effect of bundle branch block on cardiac output : A whole heart simulation study. In: Progress in Biophysics and Molecular Biology. 2008 ; Vol. 97, No. 2-3. pp. 520-542.
@article{eba73232077040088edff7deb15c5f54,
title = "Effect of bundle branch block on cardiac output: A whole heart simulation study",
abstract = "The heart is an electrically controlled fluid pump which operates by mechanical contraction. Whole heart modelling is a computationally daunting task which must incorporate several subsystems: mechanical, electrical, and fluidic. Numerous feedback mechanisms on many levels, and operating at different scales, exist to finely control behaviour. Understanding these interactions is necessary to understand heart operation, as well as pathologies and therapies. A review of the components in such a model is given. The authors then present a framework for their electro-mechano-fluidic whole heart model based on cable methods. The model incorporates atria and ventricles, and has functioning valves with papillary muscles. The effect of altered propagation due to left and right bundle branch block on cardiac output is examined using the cable-based model. Results are compared to clinically observed phenomena. Good agreement was obtained, but tighter coupling of mechanical and electrical events is needed to fully account for behaviour. Cable-based models offer an alternative to continuum models.",
keywords = "Bundle branch block, Immersed boundary method, Navier-Stokes",
author = "Vigmond, {Edward J.} and Clyde Clements and McQueen, {David M.} and Charles Peskin",
year = "2008",
month = "6",
doi = "10.1016/j.pbiomolbio.2008.02.022",
language = "English (US)",
volume = "97",
pages = "520--542",
journal = "Progress in Biophysics and Molecular Biology",
issn = "0079-6107",
publisher = "Elsevier Limited",
number = "2-3",

}

TY - JOUR

T1 - Effect of bundle branch block on cardiac output

T2 - A whole heart simulation study

AU - Vigmond, Edward J.

AU - Clements, Clyde

AU - McQueen, David M.

AU - Peskin, Charles

PY - 2008/6

Y1 - 2008/6

N2 - The heart is an electrically controlled fluid pump which operates by mechanical contraction. Whole heart modelling is a computationally daunting task which must incorporate several subsystems: mechanical, electrical, and fluidic. Numerous feedback mechanisms on many levels, and operating at different scales, exist to finely control behaviour. Understanding these interactions is necessary to understand heart operation, as well as pathologies and therapies. A review of the components in such a model is given. The authors then present a framework for their electro-mechano-fluidic whole heart model based on cable methods. The model incorporates atria and ventricles, and has functioning valves with papillary muscles. The effect of altered propagation due to left and right bundle branch block on cardiac output is examined using the cable-based model. Results are compared to clinically observed phenomena. Good agreement was obtained, but tighter coupling of mechanical and electrical events is needed to fully account for behaviour. Cable-based models offer an alternative to continuum models.

AB - The heart is an electrically controlled fluid pump which operates by mechanical contraction. Whole heart modelling is a computationally daunting task which must incorporate several subsystems: mechanical, electrical, and fluidic. Numerous feedback mechanisms on many levels, and operating at different scales, exist to finely control behaviour. Understanding these interactions is necessary to understand heart operation, as well as pathologies and therapies. A review of the components in such a model is given. The authors then present a framework for their electro-mechano-fluidic whole heart model based on cable methods. The model incorporates atria and ventricles, and has functioning valves with papillary muscles. The effect of altered propagation due to left and right bundle branch block on cardiac output is examined using the cable-based model. Results are compared to clinically observed phenomena. Good agreement was obtained, but tighter coupling of mechanical and electrical events is needed to fully account for behaviour. Cable-based models offer an alternative to continuum models.

KW - Bundle branch block

KW - Immersed boundary method

KW - Navier-Stokes

UR - http://www.scopus.com/inward/record.url?scp=46549089367&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46549089367&partnerID=8YFLogxK

U2 - 10.1016/j.pbiomolbio.2008.02.022

DO - 10.1016/j.pbiomolbio.2008.02.022

M3 - Article

VL - 97

SP - 520

EP - 542

JO - Progress in Biophysics and Molecular Biology

JF - Progress in Biophysics and Molecular Biology

SN - 0079-6107

IS - 2-3

ER -