Effect of antiretroviral therapy (ARVT) on viral load (VL) in pediatric HIV infection

Rosemary Johann-Liang, Murli Purswani, David Pearson, Tony Hinds Claudia Grassey, Ann Margaret Dunn, Joseph Stavola, Joseph Cervia, Gary Noel

Research output: Contribution to journalArticle

Abstract

Recent availability of VL monitoring and multiple ARVT have ushered in a new era of medical management in patients (pts) with HIV. Studies in adults have demonstrated dramatic reductions in VL following the use of newer ARVT. We analyzed our first experiences in utilizing VL monitoring in a pediatric clinical setting, to examine the effect of changing ARVT on VL in children. VL was measured by the Roche-Amplicor PCR HIV Monitor Test. Of pts 1-13 yrs who had at least one VL between 7/96 - 12/96, 6 pts had a change in ARVT 4 weeks prior to the first VL (C), 23 pts had change 4-12 weeks prior to VL (B), and 35 had ARVT change >12 weeks prior to VL (A). Mean ± SD VL (copies/ml) and CD4 index (CD4 count/ 50% for age) were compared between these 3 groups. Viral Load CD4 Index p values (for VL) A 180,760±229,530 .42±37 A v B:

Original languageEnglish (US)
Pages (from-to)446
Number of pages1
JournalClinical Infectious Diseases
Volume25
Issue number2
StatePublished - 1997

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Viral Load
HIV Infections
Pediatrics
Therapeutics
HIV
CD4 Lymphocyte Count
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Immunology

Cite this

Johann-Liang, R., Purswani, M., Pearson, D., Grassey, T. H. C., Dunn, A. M., Stavola, J., ... Noel, G. (1997). Effect of antiretroviral therapy (ARVT) on viral load (VL) in pediatric HIV infection. Clinical Infectious Diseases, 25(2), 446.

Effect of antiretroviral therapy (ARVT) on viral load (VL) in pediatric HIV infection. / Johann-Liang, Rosemary; Purswani, Murli; Pearson, David; Grassey, Tony Hinds Claudia; Dunn, Ann Margaret; Stavola, Joseph; Cervia, Joseph; Noel, Gary.

In: Clinical Infectious Diseases, Vol. 25, No. 2, 1997, p. 446.

Research output: Contribution to journalArticle

Johann-Liang, R, Purswani, M, Pearson, D, Grassey, THC, Dunn, AM, Stavola, J, Cervia, J & Noel, G 1997, 'Effect of antiretroviral therapy (ARVT) on viral load (VL) in pediatric HIV infection', Clinical Infectious Diseases, vol. 25, no. 2, pp. 446.
Johann-Liang R, Purswani M, Pearson D, Grassey THC, Dunn AM, Stavola J et al. Effect of antiretroviral therapy (ARVT) on viral load (VL) in pediatric HIV infection. Clinical Infectious Diseases. 1997;25(2):446.
Johann-Liang, Rosemary ; Purswani, Murli ; Pearson, David ; Grassey, Tony Hinds Claudia ; Dunn, Ann Margaret ; Stavola, Joseph ; Cervia, Joseph ; Noel, Gary. / Effect of antiretroviral therapy (ARVT) on viral load (VL) in pediatric HIV infection. In: Clinical Infectious Diseases. 1997 ; Vol. 25, No. 2. pp. 446.
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