Abstract
The purposes of this systematic literature review were to identify research-based evidence for an effect of antimicrobial therapeutic approaches on the cariogenic microbiota and early childhood caries (ECC) outcomes; and to review methods used to perform microbial assessments in clinical studies of ECC. Methods: Multiple databases were searched; only clinical cohort studies and randomized controlled trials published from 1998 to 2014 were selected. A total of 471 titles and abstracts were identified; 114 studies met the inclusion criteria for a full review, from which 41 studies were included in the meta-analyses. Results: In most of the reviewed studies, moderate reductions in cariogenic bacterial levels, mainly in mutans streptococci (MS), were demonstrated following the use of antimicrobial agents, but bacterial regrowth occurred and new carious lesions developed once the treatment had ceased, particularly in high-risk children. Relatively consistent findings suggested that anti-cariogenic microbial interventions in mothers significantly reduced MS acquisition by children. However, studies of the longterm benefits of ECC prevention are lacking. Conclusion: Based on the meta-analyses, antimicrobial interventions and treatments show temporary reductions in MS colonization levels. However, there is insufficient evidence to indicate that the approaches used produced sustainable effects on cariogenic microbial colonization or ECC reduction and prevention.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 226-244 |
| Number of pages | 19 |
| Journal | Pediatric Dentistry |
| Volume | 37 |
| Issue number | 3 |
| State | Published - May 1 2015 |
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Keywords
- DENTAL CARIES
- ORAL MICROBIOTA
- TREATMENT EFFECTIVENESS
ASJC Scopus subject areas
- Dentistry(all)
Cite this
Effect of antimicrobial interventions on the oral microbiota associated with early childhood caries. / Li, Yihong; Tanner, Anne.
In: Pediatric Dentistry, Vol. 37, No. 3, 01.05.2015, p. 226-244.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of antimicrobial interventions on the oral microbiota associated with early childhood caries
AU - Li, Yihong
AU - Tanner, Anne
PY - 2015/5/1
Y1 - 2015/5/1
N2 - The purposes of this systematic literature review were to identify research-based evidence for an effect of antimicrobial therapeutic approaches on the cariogenic microbiota and early childhood caries (ECC) outcomes; and to review methods used to perform microbial assessments in clinical studies of ECC. Methods: Multiple databases were searched; only clinical cohort studies and randomized controlled trials published from 1998 to 2014 were selected. A total of 471 titles and abstracts were identified; 114 studies met the inclusion criteria for a full review, from which 41 studies were included in the meta-analyses. Results: In most of the reviewed studies, moderate reductions in cariogenic bacterial levels, mainly in mutans streptococci (MS), were demonstrated following the use of antimicrobial agents, but bacterial regrowth occurred and new carious lesions developed once the treatment had ceased, particularly in high-risk children. Relatively consistent findings suggested that anti-cariogenic microbial interventions in mothers significantly reduced MS acquisition by children. However, studies of the longterm benefits of ECC prevention are lacking. Conclusion: Based on the meta-analyses, antimicrobial interventions and treatments show temporary reductions in MS colonization levels. However, there is insufficient evidence to indicate that the approaches used produced sustainable effects on cariogenic microbial colonization or ECC reduction and prevention.
AB - The purposes of this systematic literature review were to identify research-based evidence for an effect of antimicrobial therapeutic approaches on the cariogenic microbiota and early childhood caries (ECC) outcomes; and to review methods used to perform microbial assessments in clinical studies of ECC. Methods: Multiple databases were searched; only clinical cohort studies and randomized controlled trials published from 1998 to 2014 were selected. A total of 471 titles and abstracts were identified; 114 studies met the inclusion criteria for a full review, from which 41 studies were included in the meta-analyses. Results: In most of the reviewed studies, moderate reductions in cariogenic bacterial levels, mainly in mutans streptococci (MS), were demonstrated following the use of antimicrobial agents, but bacterial regrowth occurred and new carious lesions developed once the treatment had ceased, particularly in high-risk children. Relatively consistent findings suggested that anti-cariogenic microbial interventions in mothers significantly reduced MS acquisition by children. However, studies of the longterm benefits of ECC prevention are lacking. Conclusion: Based on the meta-analyses, antimicrobial interventions and treatments show temporary reductions in MS colonization levels. However, there is insufficient evidence to indicate that the approaches used produced sustainable effects on cariogenic microbial colonization or ECC reduction and prevention.
KW - DENTAL CARIES
KW - ORAL MICROBIOTA
KW - TREATMENT EFFECTIVENESS
UR - http://www.scopus.com/inward/record.url?scp=84944035541&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944035541&partnerID=8YFLogxK
M3 - Article
C2 - 26063552
AN - SCOPUS:84944035541
VL - 37
SP - 226
EP - 244
JO - Pediatric Dentistry
JF - Pediatric Dentistry
SN - 0164-1263
IS - 3
ER -