Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis

Takahiro Takahashi, Takehiro Watanabe, Hiroshi Nakada, Yasuhiro Tanimoto, Suguru Kimoto, Dindo Q. Mijares, Yu Zhang, Yasuhiko Kawai

Research output: Contribution to journalArticle

Abstract

Purpose: Osteoporosis contributes to impaired bone regeneration and remodeling through an imbalance of osteoblastic and osteoclastic activity, and can delay peri-implant bone formation after dental implant surgery, resulting in a prolonged treatment period. It poses several difficulties for individuals with large edentulous areas, and decreases their quality of life. Consequently, prompt postoperative placement of the final prosthesis is very important clinically. Peri-implant bone formation may be enhanced by systemic approaches, such as the use of osteoporosis supplements, to promote bone metabolism. We aimed to confirm whether intake of synthetic bone mineral (SBM), a supplement developed for osteoporosis, could effectively accelerate peri-implant bone formation in a rat model of osteoporosis. Methods: Thirty-six 7-week-old ovariectomized female Wistar rats were randomly assigned to receive a standardized diet with or without SBM (Diet with SBM group and Diet without SBM group, respectively; n = 18 for both). The rats underwent implant surgery at 9 weeks of age under general anesthesia. The main outcome measures, bone mineral density (BMD) and pull-out strength of the implant from the femur, were compared at 2 and 4 weeks after implantation using the Mann-Whitney U test. Results: Pull-out strength and BMD in the Diet with SBM group were significantly greater than those in the Diet without SBM group at 2 and 4 weeks after implantation. Conclusions: This study demonstrated that SBM could be effective in accelerating peri-implant bone formation in osteoporosis.

Original languageEnglish (US)
Pages (from-to)131-137
Number of pages7
JournalJournal of Prosthodontic Research
Volume60
Issue number2
DOIs
StatePublished - Apr 1 2016

Fingerprint

Dietary Supplements
Osteoporosis
Minerals
Formulated Food
Bone and Bones
Osteogenesis
Bone Density
Bone Regeneration
Dental Implants
Bone Remodeling
Nonparametric Statistics
Femur
General Anesthesia
Prostheses and Implants
Wistar Rats
Quality of Life
Outcome Assessment (Health Care)
Diet

Keywords

  • Animal study
  • Bone formation
  • Implant
  • Supplement

ASJC Scopus subject areas

  • Dentistry (miscellaneous)
  • Oral Surgery

Cite this

Takahashi, T., Watanabe, T., Nakada, H., Tanimoto, Y., Kimoto, S., Mijares, D. Q., ... Kawai, Y. (2016). Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis. Journal of Prosthodontic Research, 60(2), 131-137. https://doi.org/10.1016/j.jpor.2015.12.006

Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis. / Takahashi, Takahiro; Watanabe, Takehiro; Nakada, Hiroshi; Tanimoto, Yasuhiro; Kimoto, Suguru; Mijares, Dindo Q.; Zhang, Yu; Kawai, Yasuhiko.

In: Journal of Prosthodontic Research, Vol. 60, No. 2, 01.04.2016, p. 131-137.

Research output: Contribution to journalArticle

Takahashi, T, Watanabe, T, Nakada, H, Tanimoto, Y, Kimoto, S, Mijares, DQ, Zhang, Y & Kawai, Y 2016, 'Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis', Journal of Prosthodontic Research, vol. 60, no. 2, pp. 131-137. https://doi.org/10.1016/j.jpor.2015.12.006
Takahashi, Takahiro ; Watanabe, Takehiro ; Nakada, Hiroshi ; Tanimoto, Yasuhiro ; Kimoto, Suguru ; Mijares, Dindo Q. ; Zhang, Yu ; Kawai, Yasuhiko. / Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis. In: Journal of Prosthodontic Research. 2016 ; Vol. 60, No. 2. pp. 131-137.
@article{a13a4b0b54b34c648b2932b99e4c61f9,
title = "Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis",
abstract = "Purpose: Osteoporosis contributes to impaired bone regeneration and remodeling through an imbalance of osteoblastic and osteoclastic activity, and can delay peri-implant bone formation after dental implant surgery, resulting in a prolonged treatment period. It poses several difficulties for individuals with large edentulous areas, and decreases their quality of life. Consequently, prompt postoperative placement of the final prosthesis is very important clinically. Peri-implant bone formation may be enhanced by systemic approaches, such as the use of osteoporosis supplements, to promote bone metabolism. We aimed to confirm whether intake of synthetic bone mineral (SBM), a supplement developed for osteoporosis, could effectively accelerate peri-implant bone formation in a rat model of osteoporosis. Methods: Thirty-six 7-week-old ovariectomized female Wistar rats were randomly assigned to receive a standardized diet with or without SBM (Diet with SBM group and Diet without SBM group, respectively; n = 18 for both). The rats underwent implant surgery at 9 weeks of age under general anesthesia. The main outcome measures, bone mineral density (BMD) and pull-out strength of the implant from the femur, were compared at 2 and 4 weeks after implantation using the Mann-Whitney U test. Results: Pull-out strength and BMD in the Diet with SBM group were significantly greater than those in the Diet without SBM group at 2 and 4 weeks after implantation. Conclusions: This study demonstrated that SBM could be effective in accelerating peri-implant bone formation in osteoporosis.",
keywords = "Animal study, Bone formation, Implant, Supplement",
author = "Takahiro Takahashi and Takehiro Watanabe and Hiroshi Nakada and Yasuhiro Tanimoto and Suguru Kimoto and Mijares, {Dindo Q.} and Yu Zhang and Yasuhiko Kawai",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.jpor.2015.12.006",
language = "English (US)",
volume = "60",
pages = "131--137",
journal = "Journal of Prosthodontic Research",
issn = "1883-1958",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Effect of a dietary supplement on peri-implant bone strength in a rat model of osteoporosis

AU - Takahashi, Takahiro

AU - Watanabe, Takehiro

AU - Nakada, Hiroshi

AU - Tanimoto, Yasuhiro

AU - Kimoto, Suguru

AU - Mijares, Dindo Q.

AU - Zhang, Yu

AU - Kawai, Yasuhiko

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Purpose: Osteoporosis contributes to impaired bone regeneration and remodeling through an imbalance of osteoblastic and osteoclastic activity, and can delay peri-implant bone formation after dental implant surgery, resulting in a prolonged treatment period. It poses several difficulties for individuals with large edentulous areas, and decreases their quality of life. Consequently, prompt postoperative placement of the final prosthesis is very important clinically. Peri-implant bone formation may be enhanced by systemic approaches, such as the use of osteoporosis supplements, to promote bone metabolism. We aimed to confirm whether intake of synthetic bone mineral (SBM), a supplement developed for osteoporosis, could effectively accelerate peri-implant bone formation in a rat model of osteoporosis. Methods: Thirty-six 7-week-old ovariectomized female Wistar rats were randomly assigned to receive a standardized diet with or without SBM (Diet with SBM group and Diet without SBM group, respectively; n = 18 for both). The rats underwent implant surgery at 9 weeks of age under general anesthesia. The main outcome measures, bone mineral density (BMD) and pull-out strength of the implant from the femur, were compared at 2 and 4 weeks after implantation using the Mann-Whitney U test. Results: Pull-out strength and BMD in the Diet with SBM group were significantly greater than those in the Diet without SBM group at 2 and 4 weeks after implantation. Conclusions: This study demonstrated that SBM could be effective in accelerating peri-implant bone formation in osteoporosis.

AB - Purpose: Osteoporosis contributes to impaired bone regeneration and remodeling through an imbalance of osteoblastic and osteoclastic activity, and can delay peri-implant bone formation after dental implant surgery, resulting in a prolonged treatment period. It poses several difficulties for individuals with large edentulous areas, and decreases their quality of life. Consequently, prompt postoperative placement of the final prosthesis is very important clinically. Peri-implant bone formation may be enhanced by systemic approaches, such as the use of osteoporosis supplements, to promote bone metabolism. We aimed to confirm whether intake of synthetic bone mineral (SBM), a supplement developed for osteoporosis, could effectively accelerate peri-implant bone formation in a rat model of osteoporosis. Methods: Thirty-six 7-week-old ovariectomized female Wistar rats were randomly assigned to receive a standardized diet with or without SBM (Diet with SBM group and Diet without SBM group, respectively; n = 18 for both). The rats underwent implant surgery at 9 weeks of age under general anesthesia. The main outcome measures, bone mineral density (BMD) and pull-out strength of the implant from the femur, were compared at 2 and 4 weeks after implantation using the Mann-Whitney U test. Results: Pull-out strength and BMD in the Diet with SBM group were significantly greater than those in the Diet without SBM group at 2 and 4 weeks after implantation. Conclusions: This study demonstrated that SBM could be effective in accelerating peri-implant bone formation in osteoporosis.

KW - Animal study

KW - Bone formation

KW - Implant

KW - Supplement

UR - http://www.scopus.com/inward/record.url?scp=84954357788&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84954357788&partnerID=8YFLogxK

U2 - 10.1016/j.jpor.2015.12.006

DO - 10.1016/j.jpor.2015.12.006

M3 - Article

C2 - 26787534

AN - SCOPUS:84954357788

VL - 60

SP - 131

EP - 137

JO - Journal of Prosthodontic Research

JF - Journal of Prosthodontic Research

SN - 1883-1958

IS - 2

ER -