Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits

Sebnem N. Tuncdemir, Brie Wamsley, Floor J. Stam, Fumitaka Osakada, Martyn Goulding, Edward M. Callaway, Bernardo Rudy, Gord Fishell

Research output: Contribution to journalArticle

Abstract

The precise connectivity of somatostatin and parvalbumin cortical interneurons is generated during development. An understanding of how these interneuron classes incorporate into cortical circuitry is incomplete but essential to elucidate the roles they play during maturation. Here, we report that somatostatin interneurons in infragranular layers receive dense but transient innervation from thalamocortical afferents during the first postnatal week. During this period, parvalbumin interneurons and pyramidal neurons within the same layers receive weaker thalamocortical inputs, yet are strongly innervated by somatostatin interneurons. Further, upon disruption of the early (but not late) somatostatin interneuron network, the synaptic maturation of thalamocortical inputs onto parvalbumin interneurons is perturbed. These results suggest that infragranular somatostatin interneurons exhibit a transient early synaptic connectivity that is essential for the establishment of thalamic feedforward inhibition mediated by parvalbumin interneurons. Tuncdemir et al. show that L5/6 SST interneurons transiently receive selective thalamocortical innervation and provide output to PV interneurons and pyramidal neurons. SST interneurons during this period are required for the synaptic maturation of PV interneurons.

Original languageEnglish (US)
Pages (from-to)521-535
Number of pages15
JournalNeuron
Volume89
Issue number3
DOIs
StatePublished - Feb 3 2016

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tuncdemir, S. N., Wamsley, B., Stam, F. J., Osakada, F., Goulding, M., Callaway, E. M., Rudy, B., & Fishell, G. (2016). Early Somatostatin Interneuron Connectivity Mediates the Maturation of Deep Layer Cortical Circuits. Neuron, 89(3), 521-535. https://doi.org/10.1016/j.neuron.2015.11.020