Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei

Ronald A. Cohen, Stuart Grieve, Karin F. Hoth, Robert H. Paul, Lawrence Sweet, David Tate, John Gunstad, Laura Stroud, Jeanne McCaffery, Brian Hitsman, Raymond Niaura, C. Richard Clark, Alexander MacFarlane, Richard Bryant, Evian Gordon, Leanne M. Williams

Research output: Contribution to journalArticle

Abstract

Background: Early life stress (ELS) is linked to adult psychopathology and may contribute to long-term brain alterations, as suggested by studies of women who suffered childhood sexual abuse. We examine whether reported adverse ELS defined as stressful and/or traumatic adverse childhood events (ACEs) is associated with smaller limbic and basal ganglia volumes. Method: 265 healthy Australian men and women without psychopathology or brain disorders were studied. ACEs were assessed by the ELSQ and current emotional state by the DASS. Anterior cingulate cortex (ACC), hippocampus, amygdala, and caudate nucleus volumes were measured from T1-weighted MRI. Analyses examined ROI volumetric associations with reported ACEs and DASS scores. Results: Participants with greater than two ACEs had smaller ACC and caudate nuclei than those without ACEs. A significant association between total ACEs and ROI volumes for these structures was observed. Regression analysis also revealed that ELS was more strongly associated than current emotional state (DASS) with these ROI volumes. Conclusions: Reported ELS is associated with smaller ACC and caudate volumes, but not the hippocampal or amygdala volumes. The reasons for these brain effects are not entirely clear, but may reflect the influence of early stress and traumatic events on the developing brain.

Original languageEnglish (US)
Pages (from-to)975-982
Number of pages8
JournalBiological Psychiatry
Volume59
Issue number10
DOIs
StatePublished - May 15 2006

Fingerprint

Caudate Nucleus
Gyrus Cinguli
Psychological Stress
Amygdala
Psychopathology
Brain
Sex Offenses
Brain Diseases
Basal Ganglia
Hippocampus
Regression Analysis

Keywords

  • adverse childhood events
  • amygdala
  • anterior cingulate cortex
  • brain morphometry
  • caudate nucleus
  • Early life stress
  • hippocampus
  • MRI

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Cohen, R. A., Grieve, S., Hoth, K. F., Paul, R. H., Sweet, L., Tate, D., ... Williams, L. M. (2006). Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei. Biological Psychiatry, 59(10), 975-982. https://doi.org/10.1016/j.biopsych.2005.12.016

Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei. / Cohen, Ronald A.; Grieve, Stuart; Hoth, Karin F.; Paul, Robert H.; Sweet, Lawrence; Tate, David; Gunstad, John; Stroud, Laura; McCaffery, Jeanne; Hitsman, Brian; Niaura, Raymond; Clark, C. Richard; MacFarlane, Alexander; Bryant, Richard; Gordon, Evian; Williams, Leanne M.

In: Biological Psychiatry, Vol. 59, No. 10, 15.05.2006, p. 975-982.

Research output: Contribution to journalArticle

Cohen, RA, Grieve, S, Hoth, KF, Paul, RH, Sweet, L, Tate, D, Gunstad, J, Stroud, L, McCaffery, J, Hitsman, B, Niaura, R, Clark, CR, MacFarlane, A, Bryant, R, Gordon, E & Williams, LM 2006, 'Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei', Biological Psychiatry, vol. 59, no. 10, pp. 975-982. https://doi.org/10.1016/j.biopsych.2005.12.016
Cohen, Ronald A. ; Grieve, Stuart ; Hoth, Karin F. ; Paul, Robert H. ; Sweet, Lawrence ; Tate, David ; Gunstad, John ; Stroud, Laura ; McCaffery, Jeanne ; Hitsman, Brian ; Niaura, Raymond ; Clark, C. Richard ; MacFarlane, Alexander ; Bryant, Richard ; Gordon, Evian ; Williams, Leanne M. / Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei. In: Biological Psychiatry. 2006 ; Vol. 59, No. 10. pp. 975-982.
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