Early chordate origins of the vertebrate second heart field

Alberto Stolfi, T. Blair Gainous, John J. Young, Alessandro Mori, Michael Levine, Lionel Christiaen

Research output: Contribution to journalArticle

Abstract

The vertebrate heart is formed from diverse embryonic territories, including the first and second heart fields. The second heart field (SHF) gives rise to the right ventricle and outflow tract, yet its evolutionary origins are unclear. We found that heart progenitor cells of the simple chordate Ciona intestinalis also generate precursors of the atrial siphon muscles (ASMs). These precursors express Islet and Tbx1/10, evocative of the splanchnic mesoderm that produces the lower jaw muscles and SHF of vertebrates. Evidence is presented that the transcription factor COE is a critical determinant of ASM fate. We propose that the last common ancestor of tunicates and vertebrates possessed multipotent cardiopharyngeal muscle precursors, and that their reallocation might have contributed to the emergence of the SHF.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalScience
Volume329
Issue number5991
DOIs
StatePublished - Jul 30 2010

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Chordata
Vertebrates
Muscles
Ciona intestinalis
Urochordata
Viscera
Mesoderm
Jaw
Heart Ventricles
Myocardium
Transcription Factors
Stem Cells

ASJC Scopus subject areas

  • General

Cite this

Stolfi, A., Gainous, T. B., Young, J. J., Mori, A., Levine, M., & Christiaen, L. (2010). Early chordate origins of the vertebrate second heart field. Science, 329(5991), 565-568. https://doi.org/10.1126/science.1190181

Early chordate origins of the vertebrate second heart field. / Stolfi, Alberto; Gainous, T. Blair; Young, John J.; Mori, Alessandro; Levine, Michael; Christiaen, Lionel.

In: Science, Vol. 329, No. 5991, 30.07.2010, p. 565-568.

Research output: Contribution to journalArticle

Stolfi, A, Gainous, TB, Young, JJ, Mori, A, Levine, M & Christiaen, L 2010, 'Early chordate origins of the vertebrate second heart field', Science, vol. 329, no. 5991, pp. 565-568. https://doi.org/10.1126/science.1190181
Stolfi A, Gainous TB, Young JJ, Mori A, Levine M, Christiaen L. Early chordate origins of the vertebrate second heart field. Science. 2010 Jul 30;329(5991):565-568. https://doi.org/10.1126/science.1190181
Stolfi, Alberto ; Gainous, T. Blair ; Young, John J. ; Mori, Alessandro ; Levine, Michael ; Christiaen, Lionel. / Early chordate origins of the vertebrate second heart field. In: Science. 2010 ; Vol. 329, No. 5991. pp. 565-568.
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