Dynamics of double stranded DNA reptation from bacteriophage

I. S. Gabashvili, A. Y. Grosberg

    Research output: Contribution to journalArticle

    Abstract

    The dynamics of dsDNA release process from a phage head has been analyzed theoretically. The process was considered as dsDNA reptation through the phage tail. The driving force is assumed to be the decrease of the DNA globule free energy on its releasing from the head in the surrounding medium. The results of the equilibrium theory on an intraphage DNA globule were applied. Three possible sources of friction were examined. The first one is in the inner channel of the tail. The second is the friction of DNA segments in the whole globule volume, which is essential when the globule decondensation is a collective process, at simultaneous moving of all the turns (mechanism 1). The third is the globule friction with the capsid inner surface, that is most important when decondensation proceeds via the globule rotation as a whole spool (mechanism 2). Mechanism 1 would require a lot of time for ejection. Mechanism 2 would lead to different ejection dynamics of short- and long-tailed phages. Comparison of the theoretical results with the published experimental data argues in favor of mechanism 2.

    Original languageEnglish (US)
    Pages (from-to)911-920
    Number of pages10
    JournalJournal of Biomolecular Structure and Dynamics
    Volume9
    Issue number5
    StatePublished - 1992

    Fingerprint

    Friction
    Bacteriophages
    DNA
    Capsid
    Head

    ASJC Scopus subject areas

    • Molecular Biology
    • Structural Biology

    Cite this

    Dynamics of double stranded DNA reptation from bacteriophage. / Gabashvili, I. S.; Grosberg, A. Y.

    In: Journal of Biomolecular Structure and Dynamics, Vol. 9, No. 5, 1992, p. 911-920.

    Research output: Contribution to journalArticle

    Gabashvili, I. S. ; Grosberg, A. Y. / Dynamics of double stranded DNA reptation from bacteriophage. In: Journal of Biomolecular Structure and Dynamics. 1992 ; Vol. 9, No. 5. pp. 911-920.
    @article{1cc31c74fd3d4045a24ba131ab9eaf7e,
    title = "Dynamics of double stranded DNA reptation from bacteriophage",
    abstract = "The dynamics of dsDNA release process from a phage head has been analyzed theoretically. The process was considered as dsDNA reptation through the phage tail. The driving force is assumed to be the decrease of the DNA globule free energy on its releasing from the head in the surrounding medium. The results of the equilibrium theory on an intraphage DNA globule were applied. Three possible sources of friction were examined. The first one is in the inner channel of the tail. The second is the friction of DNA segments in the whole globule volume, which is essential when the globule decondensation is a collective process, at simultaneous moving of all the turns (mechanism 1). The third is the globule friction with the capsid inner surface, that is most important when decondensation proceeds via the globule rotation as a whole spool (mechanism 2). Mechanism 1 would require a lot of time for ejection. Mechanism 2 would lead to different ejection dynamics of short- and long-tailed phages. Comparison of the theoretical results with the published experimental data argues in favor of mechanism 2.",
    author = "Gabashvili, {I. S.} and Grosberg, {A. Y.}",
    year = "1992",
    language = "English (US)",
    volume = "9",
    pages = "911--920",
    journal = "Journal of Biomolecular Structure and Dynamics",
    issn = "0739-1102",
    publisher = "Adenine Press",
    number = "5",

    }

    TY - JOUR

    T1 - Dynamics of double stranded DNA reptation from bacteriophage

    AU - Gabashvili, I. S.

    AU - Grosberg, A. Y.

    PY - 1992

    Y1 - 1992

    N2 - The dynamics of dsDNA release process from a phage head has been analyzed theoretically. The process was considered as dsDNA reptation through the phage tail. The driving force is assumed to be the decrease of the DNA globule free energy on its releasing from the head in the surrounding medium. The results of the equilibrium theory on an intraphage DNA globule were applied. Three possible sources of friction were examined. The first one is in the inner channel of the tail. The second is the friction of DNA segments in the whole globule volume, which is essential when the globule decondensation is a collective process, at simultaneous moving of all the turns (mechanism 1). The third is the globule friction with the capsid inner surface, that is most important when decondensation proceeds via the globule rotation as a whole spool (mechanism 2). Mechanism 1 would require a lot of time for ejection. Mechanism 2 would lead to different ejection dynamics of short- and long-tailed phages. Comparison of the theoretical results with the published experimental data argues in favor of mechanism 2.

    AB - The dynamics of dsDNA release process from a phage head has been analyzed theoretically. The process was considered as dsDNA reptation through the phage tail. The driving force is assumed to be the decrease of the DNA globule free energy on its releasing from the head in the surrounding medium. The results of the equilibrium theory on an intraphage DNA globule were applied. Three possible sources of friction were examined. The first one is in the inner channel of the tail. The second is the friction of DNA segments in the whole globule volume, which is essential when the globule decondensation is a collective process, at simultaneous moving of all the turns (mechanism 1). The third is the globule friction with the capsid inner surface, that is most important when decondensation proceeds via the globule rotation as a whole spool (mechanism 2). Mechanism 1 would require a lot of time for ejection. Mechanism 2 would lead to different ejection dynamics of short- and long-tailed phages. Comparison of the theoretical results with the published experimental data argues in favor of mechanism 2.

    UR - http://www.scopus.com/inward/record.url?scp=0026720147&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0026720147&partnerID=8YFLogxK

    M3 - Article

    VL - 9

    SP - 911

    EP - 920

    JO - Journal of Biomolecular Structure and Dynamics

    JF - Journal of Biomolecular Structure and Dynamics

    SN - 0739-1102

    IS - 5

    ER -