Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors into the Cortical Plate

Goichi Miyoshi, Gordon Fishell

    Research output: Contribution to journalArticle

    Abstract

    Pyramidal cells of the cerebral cortex are born in the ventricular zone and migrate through the intermediate zone to enter into the cortical plate. In the intermediate zone, these migrating precursors move tangentially and initiate the extension of their axons by transiently adopting a characteristic multipolar morphology. We observe that expression of the forkhead transcription factor . FoxG1 is dynamically regulated during this transitional period. By utilizing conditional genetic strategies, we show that the downregulation of . FoxG1 at the beginning of the multipolar cell phase induces . Unc5D expression, the timing of which ultimately determines the laminar identity of pyramidal neurons. In addition, we demonstrate that the re-expression of . FoxG1 is required for cells to transit out of the multipolar cell phase and to enter into the cortical plate. Thus, the dynamic expression of . FoxG1 during migration within the intermediate zone is essential for the proper assembly of the cerebral cortex.

    Original languageEnglish (US)
    Pages (from-to)1045-1058
    Number of pages14
    JournalNeuron
    Volume74
    Issue number6
    DOIs
    StatePublished - Jun 21 2012

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    Pyramidal Cells
    Cerebral Cortex
    Forkhead Transcription Factors
    Axons
    Down-Regulation

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Dynamic FoxG1 Expression Coordinates the Integration of Multipolar Pyramidal Neuron Precursors into the Cortical Plate. / Miyoshi, Goichi; Fishell, Gordon.

    In: Neuron, Vol. 74, No. 6, 21.06.2012, p. 1045-1058.

    Research output: Contribution to journalArticle

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